[1] Zhou B,Lin W,Long Y,et al.Notch signaling pathway:architecture,disease,and therapeutics[J].Signal Transduct Target Ther,2022,7(1):95. [2] Ye YC,Zhao JL,Lu YT,et al.NOTCH signaling via WNT regulates the proliferation of alternative,CCR2-Independent tumor-associated macrophages in hepatocellular carcinoma[J].Cancer Res,2019,79(16):4160-4172. [3] Caines A,Selim R,Salgia R.The changing global epidemiology of hepatocellular carcinoma[J].Clin Liver Dis,2020,24(4):535-547. [4] Zhou SJ,Deng YL,Liang HF,et al.Hepatitis B virus X protein promotes CREB-mediated activation of miR-3188 and Notch signaling in hepatocellular carcinoma[J].Cell Death Differ,2017,24(9):1577-1587. [5] Vazquez-Ulloa E,Lizano M,Sjoqvist M,et al.Deregulation of the Notch pathway as a common road in viral carcinogenesis[J].Rev Med Virol,2018,28(5):e1988-e1988. [6] Wang Z,Kawaguchi K,Honda M,et al.Distinct notch signaling expression patterns between nucleoside and nucleotide analogues treatment for hepatitis B virus infection[J].Biochem Biophys Res Commun,2018,501(3):682-687. [7] 李彧,张鸿,等.Notch信号通路对慢性丙型肝炎患者CD8+T淋巴细胞功能的影响[J].临床肝胆病杂志,2018,34(2):287-291. [8] Singal AK,Mathurin P.Diagnosis and treatment of alcohol-associated liver disease:a review[J].JAMA,2021,326(2):165-176. [9] Ganne-Carrié N,Nahon P.Hepatocellular carcinoma in the setting of alcohol-related liver disease[J].Hepatol,2019,70(2):284-293. [10] Golabi P,Rhea L,Henry L,et al.Hepatocellular carcinoma and non-alcoholic fatty liver disease[J].Hepatol Int,2019,13(6):688-694. [11] Zhu C,Kim K,Wang X,et al.Hepatocyte Notch activation induces liver fibrosis in nonalcoholic steatohepatitis[J].Sci Transl Med,2018,10(468):344. [12] Romeo S.Notch and nonalcoholic fatty liver and fibrosis[J].N Engl Med,2019,380(7):681-683. [13] Niture S,Gyamfi MA,Kedir H,et al.Serotonin induced hepatic steatosis is associated with modulation of autophagy and notch signaling pathway[J].Cell Commun Signal,2018,16(1):78-78. [14] Tsoulfas G.Hepatocellular carcinoma and metabolic syndrome:the times are changing and so should we[J].World Gastroenterol,2019,25(29):3842-3848. [15] 陈虹,陈琪,等.Notch2在肝细胞癌中的表达及相关microRNAs的筛选[J].福建医科大学学报,2021,55(3):230-236. [16] Yang X,Liu J,Liang Q,et al.Valproic acid reverses sorafenib resistance through inhibiting activated Notch/Akt signaling pathway in hepatocellular carcinoma[J].Fundam Clin Pharmacol,2021,35(4):690-699. [17] Yang X,Xia W,Chen L,et al.Synergistic antitumor effect of a γ-secretase inhibitor PF-03084014 and sorafenib in hepatocellular carcinoma[J].Oncotarget,2018,9(79):34996-35007. [18] Hessam S,Gambichler T,Skrygan M,et al.Increased expression profile of NCSTN,Notch and PI3K/AKT3 in hidradenitis suppurativa[J].Eur Acad Dermatol Venereol,2021,35(1):203-210. [19] Arai MA,Akamine R,Tsuchiya A,et al.The Notch inhibitor cowanin accelerates nicastrin degradation[J].Sci Rep,2018,8(1):5376-5376. [20] Kim K,Goldberg IJ,Graham MJ,et al.γ-secretase inhibition lowers plasma triglyceride-rich lipoproteins by stabilizing the LDL receptor[J].Cell Metab,2018,27(4):816-827. [21] Li H,Lan T,Xu L,et al.NCSTN promotes hepatocellular carcinoma cell growth and metastasis via β-catenin activation in a Notch1/AKT dependent manner[J].Exp Clin Cancer Res,2020,39(1):128.