Efficacy of Probiotic-Assisted Estramiprazole-Based Quadruple Regimen in the Treatment of Hp-Positive Gastric Ulcer and Analysis of the Effect on Intestinal Flora
YIN Yuanying, GAO Lisha, LIU Yan, et al
The West China Hospital, Sichuan University, Sichuan Chengdu 610041, China
Abstract：Objective: To investigate the efficacy of a probiotic-assisted quadruple regimen based on esomeprazole in the treatment of Helicobacter pylori (H. pylori, Hp) positive gastric ulcer and its effect on the intestinal flora. Methods: A total of 123 patients with Hp-positive gastric ulcers who were admitted to our hospital from May 2019 to May 2021 were selected for research, and they were divided into a study group (N=63) and a control group (N=60) by a simple random method using a random number table. The group was treated with a quadruple regimen based on esomeprazole, and the research group was given probiotics (Saccharomyces boulardii) on this basis. Both groups were treated for 14 days, and the Hp eradication rate, ulcer surface healing, intestinal flora, and adverse effects between the two groups were compared. Results: The rate of ulcer surface healing and Hp eradication were higher in the study group than in the control group, with statistically significant differences (P<0.05). The levels of Clostridium perfringens, Bifidobacterium, and Lactobacillus were lower in the control group than before treatment (P<0.05), while the levels of Enterobacter, Yeast, and Enterococcus were higher (P<0.05) and the B/E values were lower (P<0.05). The levels of Bifidobacterium and Lactobacillus in the study group were higher than before treatment (P<0.05), the levels of Clostridium perfringens were lower than before treatment (P<0.05), and the levels of Enterobacter, Enterococcus and Yeast were not significantly different from before treatment (P>0.05). Conclusion: The probiotic-assisted estramiprazole-based quadruple regimen for the treatment of patients with H. pylori Hp-positive gastric ulcers significantly improves clearance rates, promotes healing of the ulcer surface, and has a positive effect on promoting a balanced intestinal flora environment, making it suitable for promotion.
尹袁英, 高莉莎, 刘燕, 乔江蓉, 任宏飞, 张铭光. 益生菌辅助基于艾司奥美拉唑的四联方案治疗Hp阳性胃溃疡的疗效及对肠道菌群的影响分析[J]. 河北医学, 2022, 28(9): 1498-1501.
YIN Yuanying, GAO Lisha, LIU Yan, et al. Efficacy of Probiotic-Assisted Estramiprazole-Based Quadruple Regimen in the Treatment of Hp-Positive Gastric Ulcer and Analysis of the Effect on Intestinal Flora. HeBei Med, 2022, 28(9): 1498-1501.
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2022, Vol. 28 
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