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河北医学  2022, Vol. 28 Issue (8): 1399-1403    DOI: 10.3969/j.issn.1006-6233.2022.08.035
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不同剂量帕瑞昔布钠对直肠癌手术患者免疫指标血清S100β NSE TNF-α及IL-1β水平的影响
张龙飞, 廖兴志, 刘宇芳, 翁玲, 陆海波
中国人民解放军联勤保障部队第904医院麻醉科, 江苏 无锡 214000
Effect of Different Doses of Parecoxib Sodium on Immune Indexes, Serum S100β NSE TNF-α and IL-1β Levels in Patients Undergoing Surgery for Rectal Cancer
ZHANG Longfei, LIAO Xingzhi, LIU Yufang, et al
904 Hospital of the Joint Logistics Support Force of the Chinese People's Liberation Army, Jiangsu Wuxi 214000, China
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摘要 目的: 探究不同剂量帕瑞昔布钠对直肠癌手术患者免疫指标、S100钙结合蛋白β(S100β)、神经元特异性烯醇化酶(NSE)肿瘤坏死因子-α(TNF-α)白细胞介素-1β(IL-1β)的影响。方法: 将2018年3月至2021年6月于我院行直肠癌手术患者80例纳入研究,简单随机分为大剂量、小剂量、对照组,分别有30例、30例、20例。对照组于麻醉前20min与氯化钠(0.9%),大剂量组予40mg帕瑞昔布钠,小剂量组予20mg帕瑞昔布钠。分析比较三组术前、术后12h、24h免疫指标、血清S100β、NSE、TNF-α及IL-1β水平。结果: 大剂量组镇痛泵按压次数显著少于小剂量、对照组,小剂量显著少于对照组,差异有统计学意义(P<0.05);S100β、TNF-α、IL-1β主体内效应(F时点、F交互)、主体间效应(F组间)比较,差异有统计学意义(P<0.05),NSE仅在F时点比较上差异有统计学意义(P<0.05),而组间差异及分组与时间的交互作用均无统计学意义(P>0.05)。CD3+、CD4+主体内效应(F时点、F交互)、主体间效应(F组间)比较,差异有统计学意义(P<0.05),CD8+仅在F时点比较上差异有统计学意义(P<0.05),而组间差异及分组与时间的交互作用均无统计学意义(P>0.05)。结论: 帕瑞昔布钠可显著改善直肠癌手术患者免疫指标、血清S100β、NSE、TNF-α及IL-1β水平,使用30mg时效果更佳。
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关键词 帕瑞昔布钠直肠癌免疫指标血清S100β炎症因子    
AbstractObjective: To investigate the Effect of different doses of parecoxib sodium on immune indexes, serum S100β, NSE, TNF-α and IL-1β levels in patients undergoing surgery for rectal cancer. Methods: A total of 80 patients who underwent rectal cancer surgery in our hospital from March 2018 to June 2021 were included in the study. They were simply randomly divided into high-dose, low-dose and control groups, with 30 cases, 30 cases and 20 cases respectively. The control group was treated with sodium chloride (0.9%) 20 minutes before anesthesia , the high-dose group was given 30 mg parecoxib sodium, and the low-dose group was given 10 mg parecoxib sodium β , NSE , TNF- α And IL-1 β. Results: The number of analgesic pump presses was significantly less in the high-dose group than in the low-dose and control groups, and significantly less in the low-dose than in the control group, with statistically significant differences (P<0.05); the differences were statistically significant (P<0.05) for the comparison of intersubject effects (F time point, F interaction) and between-subject effects (F between groups) for S100β, TNF-α, IL-1β, and NSE only for the F time point comparison was statistically significant (P<0.05), while the between-group differences and group-time-interaction effects were not statistically significant (P>0.05). The differences were statistically significant (P<0.05) for the comparison of CD3+ and CD4+ within-subject effects (F time point, F interaction) and between-subject effects (F between groups), and statistically significant (P<0.05) for CD8+ only for the comparison of F time point, while neither the between-group differences nor the interaction between groups and time were statistically significant (P>0.05). Conclusion: Parecoxib sodium significantly improved immune markers, serum S100β, NSE, TNF-α and IL-1β levels in patients undergoing surgery for rectal cancer, with better results when 30mg was used.
Key wordsParecoxib sodium    Rectal cancer    Immune index    Serum S100 β    Inflammatory factor
    
基金资助:无锡市卫生计生委科研项目,(编号:T201825)
通讯作者: 廖兴志   
引用本文:   
张龙飞, 廖兴志, 刘宇芳, 翁玲, 陆海波. 不同剂量帕瑞昔布钠对直肠癌手术患者免疫指标血清S100β NSE TNF-α及IL-1β水平的影响[J]. 河北医学, 2022, 28(8): 1399-1403.
ZHANG Longfei, LIAO Xingzhi, LIU Yufang, et al. Effect of Different Doses of Parecoxib Sodium on Immune Indexes, Serum S100β NSE TNF-α and IL-1β Levels in Patients Undergoing Surgery for Rectal Cancer. HeBei Med, 2022, 28(8): 1399-1403.
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