Effect of Different Doses of Parecoxib Sodium on Immune Indexes, Serum S100β NSE TNF-α and IL-1β Levels in Patients Undergoing Surgery for Rectal Cancer
ZHANG Longfei, LIAO Xingzhi, LIU Yufang, et al
904 Hospital of the Joint Logistics Support Force of the Chinese People's Liberation Army, Jiangsu Wuxi 214000, China
Abstract：Objective: To investigate the Effect of different doses of parecoxib sodium on immune indexes, serum S100β, NSE, TNF-α and IL-1β levels in patients undergoing surgery for rectal cancer. Methods: A total of 80 patients who underwent rectal cancer surgery in our hospital from March 2018 to June 2021 were included in the study. They were simply randomly divided into high-dose, low-dose and control groups, with 30 cases, 30 cases and 20 cases respectively. The control group was treated with sodium chloride (0.9%) 20 minutes before anesthesia , the high-dose group was given 30 mg parecoxib sodium, and the low-dose group was given 10 mg parecoxib sodium β , NSE , TNF- α And IL-1 β. Results: The number of analgesic pump presses was significantly less in the high-dose group than in the low-dose and control groups, and significantly less in the low-dose than in the control group, with statistically significant differences (P<0.05); the differences were statistically significant (P<0.05) for the comparison of intersubject effects (F time point, F interaction) and between-subject effects (F between groups) for S100β, TNF-α, IL-1β, and NSE only for the F time point comparison was statistically significant (P<0.05), while the between-group differences and group-time-interaction effects were not statistically significant (P>0.05). The differences were statistically significant (P<0.05) for the comparison of CD3+ and CD4+ within-subject effects (F time point, F interaction) and between-subject effects (F between groups), and statistically significant (P<0.05) for CD8+ only for the comparison of F time point, while neither the between-group differences nor the interaction between groups and time were statistically significant (P>0.05). Conclusion: Parecoxib sodium significantly improved immune markers, serum S100β, NSE, TNF-α and IL-1β levels in patients undergoing surgery for rectal cancer, with better results when 30mg was used.
张龙飞, 廖兴志, 刘宇芳, 翁玲, 陆海波. 不同剂量帕瑞昔布钠对直肠癌手术患者免疫指标血清S100β NSE TNF-α及IL-1β水平的影响[J]. 河北医学, 2022, 28(8): 1399-1403.
ZHANG Longfei, LIAO Xingzhi, LIU Yufang, et al. Effect of Different Doses of Parecoxib Sodium on Immune Indexes, Serum S100β NSE TNF-α and IL-1β Levels in Patients Undergoing Surgery for Rectal Cancer. HeBei Med, 2022, 28(8): 1399-1403.
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2022, Vol. 28 
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