Correlation Between Fetal Growth Restriction and Abnormal Blood Flow in the Umbilical Artery and Analysis of the Relevant Influencing Factors Affecting Fetal Growth
JIANG Hongyu, ZHUANG Xiujuan, CAI Siming, et al
The Second Affiliated Hospital of Hainan Medical College, Hainan Haikou 570311, China
Abstract:Objective: To analyze the correlation between fetal growth restriction and abnormal umbilical artery blood flow and the related factors affecting fetal growth. Methods: A total of 120 pregnant women with fetal growth restriction treated in our hospital from January 2019 to January 2021 were selected as the observation group and 100 normal pregnant women as the control group. The ratio of systolic peak to diastolic peak of umbilical artery blood flow (S/D), blood resistance index (RI) and blood pulsation index (PI) of the two groups were observed, various factors leading to fetal growth restriction were analyzed, and statistically significant factors were included in multivariate logistic regression analysis to analyze the relevant independent risk factors of fetal growth restriction. Results: The indexes of S/D, PI and RI in the observation group were significantly higher than those in the control group (P<0.05); the results of univariate and multivariate logistic regression analysis showed that anemia, placental abnormality and umbilical cord abnormality were independent risk factors for fetal growth restriction. Conclusion: Pregnant women with fetal growth restriction in the abdomen will have obvious abnormalities in umbilical artery blood flow, and their blood flow resistance will also increase significantly. Anemia, placental abnormality, umbilical cord abnormality and fetal membrane abnormality are independent risk factors leading to fetal growth restriction. More clinical attention should be paid to this type of condition in pregnant women.
[1] Coffman V R,Jensen A S,Trabjerg B B,et al.Prenatal exposure to nitrate from drinking water and markers of fetal growth restriction:a population-based study of nearly one million danish-born children[J].Environmental Health Perspectives,2021,129(2):27002. [2] 张志珊,李蕊珊,欧阳春梅,等.阿司匹林与低分子肝素二联疗法对胎儿生长受限结局的影响及安全性分析[J].中国病案,2020,1(1):100-104. [3] Jazwiec P A,Li X,Matushewski B,et al.Fetal growth restriction is associated with decreased number of ovarian follicles and impaired follicle growth in young adult guinea pig offspring[J].Reproductive Sciences,2019,26(1):1557-1567. [4] 《实用妇产科学》(第3版)出版发行[J].中国临床医生,2014,(11):79-79. [5] Ohwaki A,Nishizawa H,Kato A,et al.Altered serum soluble furin and prorenin receptor levels in pregnancies with pre-eclampsia and fetal growth restriction[J].Journal of Gynecology Obstetrics and Human Reproduction,2021,50(10):102198. [6] Beard S,Pritchard N,Binder N,et al.Aurora kinase mRNA expression is reduced with increasing gestational age and in severe early onset fetal growth restriction[J].Placenta,2020,95(26):53-61. [7] 王燕,张炜芬,刘伯元,等.彩色多普勒超声检测孕晚期胎儿脐动脉及大脑中 动脉血流评估胎儿生长受限的价值[J].河北医学,2019,25(4):164-161. [8] Dai Y,Li T H,He X,et al.The Effect and mechanism of asymmetric dimethylarginine regulating trophoblastic autophagy on fetal growth restriction[J].Reproductive Sciences,2021,28(7):1-11.