Abstract：Objective: To investigate the effect of group B hemolytic streptococcus (GBS) on maternal blood coagulation, vaginal microecology and pregnancy outcome. Methods: A total of 210 pregnant women with GBS infection who were admitted to our hospital from January 2020 to February 2022 were selected as the research subjects, and 210 pregnant women with normal obstetric examination during the same period were selected as the control group. The coagulation function, vaginal microecology and pregnancy outcomes of the two groups of pregnant women were compared. and the association of GBS with coagulation function, vaginal microecology and pregnancy outcome was analyzed. Results: Patients in the study group had significantly lower AP, APTT and INR levels than the control group and significantly higher Fbg levels than the control group (P<0.05).The difference between the two groups was not statistically significant (P>0.05) when comparing positive Trichomonas vaginalis, but the rate of vaginal micro-ecological disorders, positive fungi, positive bacterial vaginosis, abnormal pH, and abnormal cleanliness was higher in the study group than in the control group, which was statistically significant (P<0.05). The incidence of caesarean section, premature rupture of membranes, puerperal infection, intrauterine infection, prematurity, pathological jaundice, neonatal infection and neonatal asphyxia was significantly higher in the study group than in the control group (P<0.05). Conclusion: Pregnant women with Group B haemolytic streptococcal (GBS) infection during pregnancy are at risk of blood hypercoagulation, vaginal microecological disorders and adverse pregnancy outcomes. Maintaining stable vaginal microecology, focusing on coagulation testing and early management can help to reduce the risk of adverse pregnancy outcomes.
2022, Vol. 28 
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