宫颈癌患者化疗前后宫颈上皮组织Bcl-2和MACCI蛋白表达及ROC预测效能

doi:10.3969/j.issn.1006-6233.2022.08.025

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摘要 目的: 探索宫颈癌患者化疗前后宫颈上皮组织B淋巴细胞瘤-2基因(Bcl-2)和结肠癌转移相关基因1蛋白(MACCI)表达情况。方法: 回顾性分析的89例宫颈上皮内瘤变(宫颈瘤变组)、121例宫颈癌患者(宫颈癌组)均在2018年3月至2020年11月期间收集,均进行化疗干预,使用免疫组化SP法检测MACCI、Bcl-2表达,比较两组患者基因蛋白表达情况后,再对比宫颈癌患者化疗前后Bcl-2、MACCI基因表达,经ROC曲线分析Bcl-2、MACCI预测效能。结果: 宫颈癌患者的MACCI表达(7.68±1.58)%、Bcl-2表达(0.29±0.04)%高于宫颈瘤变组(P<0.05),ROC曲线分析显示,MACCI、Bcl-2分别预测宫颈癌的AUC值为0.924、0.968。同时,宫颈癌患者化疗后MACCI表达(5.98±1.44)%、Bcl-2表达(0.21±0.03)%低于化疗前(P<0.05),经Spearman法分析,疗效与MACCI、Bcl-2呈正相关性;ROC曲线分析显示,MACCI、Bcl-2诊断宫颈癌的AUC值分别为0.924、0.968;MACCI、Bcl-2预测疗效的AUC值分别为0.765、0.937。结论: Bcl-2、MACCI在评估宫颈癌发生、转归中具有较高效能。

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	樊毓
	邓罕
	唐斌

关键词 ：宫颈癌, 化疗, B淋巴细胞瘤-2基因, 结肠癌转移相关基因1蛋白

Abstract：Objective: To explore the expression of B lymphocyte tumor-2 gene (Bcl-2) and colon cancer metastasis related gene 1 protein (MACCI) in cervical epithelial tissue before and after chemotherapy in patients with cervical cancer. Methods: The retrospective analysis of 89 cervical intraepithelial neoplasia (cervical neoplasia group) and 121 cervical cancer patients (cervical cancer group) were collected between March 2018 and November 2020, all of whom underwent chemotherapy intervention, and MACCI and Bcl-2 expression were detected using the immunohistochemical SP method, and after comparing the gene protein expression of the two groups, the Bcl-2 and MACCI gene expression of cervical cancer patients before and after chemotherapy was then compared, and the predictive efficacy of Bcl-2 and MACCI was analysed by ROC curve. Results: The MACCI expression (7.68 ± 1.58)% and Bcl-2 expression (0.29 ± 0.04)% were higher in cervical cancer patients than in the cervical neoplasia group (P<0.05), and ROC curve analysis showed that MACCI and Bcl-2 predicted cervical cancer with AUC values of 0.924 and 0.968, respectively. meanwhile, MACCI expression (5.98 (±1.44)% and Bcl-2 expression (0.21±0.03)% were lower than those before chemotherapy (P<0.05), and the efficacy was positively correlated with MACCI and Bcl-2 by Spearman method analysis; ROC curve analysis showed that the AUC values of MACCI and Bcl-2 for diagnosing cervical cancer were 0.924 and 0.968, respectively; the AUC values of MACCI and Bcl-2. Conclusion: Bcl-2 and MACCI are more effective in the assessment of cervical cancer incidence and regression.

Key words： Cervical cancer Chemotherapy B lymphocyte tumor-2 gene Colon cancer metastasis related gene 1 protein

基金资助:贵州省卫生健康委科学技术基金项目,(编号:gzwkj2021-381)

引用本文:

樊毓, 邓罕, 唐斌. 宫颈癌患者化疗前后宫颈上皮组织Bcl-2和MACCI蛋白表达及ROC预测效能[J]. 河北医学, 2022, 28(8): 1353-1356.
FAN Yu, DENG Han, TANG Bin. Bcl-2 and MACCI Protein Expression in Cervical Epithelial Tissue Before and After Chemotherapy in Patients with Cervical Cancer and the Predictive Efficacy of ROC. HeBei Med, 2022, 28(8): 1353-1356.

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http://www.hbyxzzs.cn/CN/10.3969/j.issn.1006-6233.2022.08.025 或 http://www.hbyxzzs.cn/CN/Y2022/V28/I8/1353

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