Effect of Microecological Preparations Supplemented with Alpha-Interferon on the Immune Function and Prognosis of Children with Asthma Combined with Mycoplasma Pneumoniae Infection
Abstract：Objective: To investigate the effect of microecological preparations supplemented with α-interferon on the immune function and prognosis of children with asthma complicated by Mycoplasma pneumoniae infection. Methods: A total of 124 children with asthma complicated by Mycoplasma pneumoniae infection who were admitted to our hospital from January 2020 to August 2021 were selected for study.They were randomly divided into the study group and the control group with 62 cases in each group.Both groups were given conventional treatment such as cough suppression,wheezing and sedation with azithromycin upon admission.The control group received α-interferon atomization inhalation therapy on the basis of this,and the study group was given probiotics adjuvant therapy on the basis of the control group.After 5 days of treatment,the pulmonary function indexes,peripheral blood CD25,serum interleukin-5 (IL-5),and total immunoglobulin E (IgE) concentrations were compared between the two groups before and after treatment,and the coughing and wheezing conditions were compared between the two groups. Results: After treatment,FEV1,FVC,FEV1/FVC in the two groups were higher than those before treatment (P<0.05),CD25,IL-5 and IgE levels in the two groups were lower than those before treatment (P<0.05),and the research group The difference before and after treatment was higher than that in the control group (P<0.05).TThe cough symptom score,mean length of stay and number of wheezing episodes ≥2 during follow-up were all lower in the study group than in the control group,and the cough disappeared earlier than in the control group (P<0.05). Conclusion: The microecological preparation supplemented with α-interferon in the treatment of children with asthma complicated by Mycoplasma pneumoniae infection has an ideal effect,and has significant advantages in improving the symptoms and prognosis of children,and has a good promotion prospect.
王丽艳, 鲍星星, 边俊梅. 微生态制剂辅助α-干扰素对哮喘合并肺炎支原体感染患儿免疫功能及预后的影响分析[J]. 河北医学, 2022, 28(7): 1209-1213.
WANG Liyan, BAO Xingxing, BIAN Junmei. Effect of Microecological Preparations Supplemented with Alpha-Interferon on the Immune Function and Prognosis of Children with Asthma Combined with Mycoplasma Pneumoniae Infection. HeBei Med, 2022, 28(7): 1209-1213.
[1] Jiang Q, Yang F, Peng Y,et al.Epidemiology and molecular identification of mycoplasma pneumoniae associated with respiratory infections in Zhejiang province,China,2008~2017[J].Journal of Clinical Laboratory Analysis,2020,34(11):e23460. [2] 程培培,任磊,周启立,等.哮喘伴肺炎支原体感染患儿RBP,IgE,IFN-γ,25(OH)D表达水平及其临床意义[J].中华医院感染学杂志,2020,30(24):3788-3792. [3] 罗再春.肺炎支原体与小儿咳嗽变异性哮喘相关性分析[J].重庆医科大学学报,2020,45(6):4. [4] Xu W, Yang H, Liu H,et al.Bronchoalveolar lavage T cell cytokine profiles and their association with lung function in children with M.pneumoniae ssociated bronchiolitis obliterans[J].Pediatric Pulmonology,2020,55(8):2033-2040. [5] 王艳蕊,王桂芳,宋丽芳,等.儿童肺炎支原体感染的流行病学特征分析[J].中国病原生物学杂志,2020,15(2):230-237. [6] 辛素芳,李力敏,刘佩.小儿柴桂退热颗粒辅助治疗肺炎支原体感染伴咳嗽变异性哮喘患儿的临床效果观察[J].临床误诊误治,2020,33(1):21-25. [7] 戴单单,朱素燕,徐萍,等.α干扰素雾化吸入的研究进展[J].中国临床药学杂志,2020,29(4):316-318. [8] 张长生,张海涛.支气管哮喘患者细胞间黏附因子-1,嗜酸粒细胞的水平变化及临床意义[J].中国医药导报,2020,17(1):94-97. [9] 雷东红,葛雯雯,闫凡,等.肺炎支原体感染与支气管哮喘患儿发病的关系及其对患儿IgE,细胞因子的影响[J].海南医学,2020,31(14):1843-1846. [10] 刘建国,林秀萍,张苑,等.复合肠道微生态制剂联合改良低碳饮食对超重或单纯性肥胖儿童食欲与体脂代谢和胃肠道反应的影响研究[J].中国全科医学,2020,23(29):3675-3681. [11] 沙曦雪,王苏弘,杨彧,等.微生态制剂对哮喘患儿疗效,心理问题及认知功能的干预效果[J].中国现代医生,2022,60(1):89-92.
2022, Vol. 28 
冀公网安备13080202000786号