Clinical Efficacy and Effect on Renal Function of Azitromycin in Combination with Huaiqihuang Granule in Children with Primary Nephrotic Syndrome Complicated with Mycoplasma Infection
ZHENG Zhifang, LIU Lirui, WANG Wentao, et al
The Affiliated Hospital of Chengde Medical University, Hebei Chengde 067000, China
Abstract：Objective: To observe the efficacy and effect on renal function of azitromycin combinde with Huaiqihuang granule for the treatment of primary nephrotic syndrome with mycoplasma pneumoniae infection. Methods: Fifty-six children with recurrent PNS and Mycoplasma pneumoniae infection were randomly divided into 2 groups,28 children in the control group and 28 children in the observation group.The control group was treated with azithromycin and the observation group was treated with azithromycin combined with Sophora citrifolium granules.The data of clinical efficacy,albumin,total cholesterol(TC),urea nitrogen(BUN),creatinine(Cr)levels were observed,and the changes in the indicators of the two groups of children were analyzed and compared.Then negative time of urinary protei,time of edema disappearance and drug reactions between the two groups were observed. Results: After treatment,the total effective rates of the treatment group and control group were 92.86% and 75.00%,respectively; the difference was statistically significant (P<0.05).The plasma albumin was (36.35±8.02) g/L and 31.08±3.79) g/L,total cholesterol was (3.40±1.50) mmoL/L and (4.41±1.17) mmoL/L,urea nitrogen was (2.92±1.48) mmoL/L and (3.78±1.16) mmoL/L in the observation and control groups,respectively.The creatinine was (46.34±19.30) μmoL/L/L and (63.55±24.44) μmoL/L/L respectively,with significant differences in the biochemical parameters between the 2 groups (all P<0.05).After treatment,the time for urine protein to turn negative was (11.75±7.10) d and (15.89±5.26) d respectively in the observation group and control group,and the time for swelling to disappear was (9.32±4.07) d and (13.36±4.54) d respectively,and the difference was significant in both groups (both P<0.05).The overall adverse drug reaction rates were 17.85% (5/28 cases) and 42.86% (12/28 cases) in the observation and control groups,respectively,with statistically significant differences between the 2 groups (P<0.05). Conclusion: Azitromycin combinde with Huaiqihuang granule is effective in children with PNS combined with mycoplasma pneumoniae infection,and can significantly improve the renal function and clinical symptoms of children with a good safety profile.
郑志方, 刘利蕊, 王文涛, 敬小青, 王波. 阿奇霉素联合槐杞黄颗粒对儿童原发性肾病综合征合并支原体感染的临床疗效及肾功能的影响[J]. 河北医学, 2022, 28(7): 1205-1209.
ZHENG Zhifang, LIU Lirui, WANG Wentao, et al. Clinical Efficacy and Effect on Renal Function of Azitromycin in Combination with Huaiqihuang Granule in Children with Primary Nephrotic Syndrome Complicated with Mycoplasma Infection. HeBei Med, 2022, 28(7): 1205-1209.
2022, Vol. 28 
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