Analysis of High Risk Factors of Elderly Lower Extremity Arteriosclerosis Obliterans and the Therapeutic Effect of Lower Extremity Arterial Bypass Grafting
ZHANG Xiong, et al
Linfen People's Hospital,Shanxi Linfen 041000, China
Abstract：Objective: To analyze the risk factors of lower extremity arteriosclerotic occlusive disease (PAD) in elderly patients and the therapeutic effect of lower extremity arterial bypass grafting. Methods: A total of 90 elderly patients with PAD admitted to our hospital from January 2019 to January 2020 were selected as the case group, and another 90 elderly patients who underwent physical examination in our hospital during the same period were selected as the physical examination group. The factors that may affect the incidence of the elderly were collected, and the risk factors for the incidence of PAD were analyzed by univariate and multivariate Logistic regression. Patients in the case group were divided into observation group (n=45) and control group (n=45) by simple random grouping.The observation group underwent lower limb artery bypass grafting, and the control group underwent endovascular angiogenesis. The indexes of posterior tibial and dorsal foot arteries, oxidative stress response [superoxide dismutase (SOD), malondialdehyde (MDA)] and postoperative adverse reactions were compared between the two groups. Results: Univariate results showed that the incidence of smoking history, hypertension, diabetes, coronary heart disease and chronic renal insufficiency were 16.67%、28.89%、27.78%、 12.22% and 18.89% in case group, significantly higher than 4.4%、15.56%、15.56%、3.33% and 5.56% of physical examination group (P<0.05); multivariate Logistic regression analysis showed that hypertension, diabetes, coronary heart disease and chronic renal insufficiency were independent risk factors for PAD in the elderly (P<0.05). After treatment, the difference of posterior tibial artery and dorsal foot artery before and after treatment in the observation group was significantly higher than that in the control group (P<0.05), SOD level was significantly lower than that in control group (P<0.05), MDA level was significantly higher than that in control group (P<0.05), and the total incidence of adverse reactions was significantly higher than that in control group (26.67% vs 8.89%, P<0.05). Conclusion: Hypertension, diabetes, coronary heart disease and chronic renal insufficiency are the high risk factors for elderly patients with PAD. Lower limb artery bypass grafting has a good effect on the treatment of elderly patients with PAD, and the oxidative stress reaction is more serious, and the incidence of postoperative adverse reactions is high. Therefore, the treatment plan can be selected according to the actual situation of patients.
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2022, Vol. 28 
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