早期间歇蓝光照射联合益生菌黄疸茵陈颗粒治疗新生儿黄疸对免疫能力黄疸指数及临床疗效的影响

doi:10.3969/j.issn.1006-6233.2022.06.010

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摘要 目的: 探讨早期间歇蓝光照射联合益生菌、黄疸茵陈颗粒对新生儿黄疸患儿的免疫能力、黄疸指数的影响及其临床疗效。方法: 选取我院2017年8月至2020年12月期间诊治的125例新生儿黄疸患儿,采用随机数字表法将所有患儿进行简单随机分组为研究组63例,对照组62例,所有患儿均采用间歇蓝光照射治疗,研究组患者在光疗的基础上联合益生菌、黄疸茵陈颗粒治疗。评估两组患儿的临床效果,计算总有效率。对比观察两组患儿治疗前后的免疫功能水平的变化,主要包括免疫球蛋白A(Immunoglobulin A,IgA)、免疫球蛋白G(Immunoglobulin G,IgG),同时对比两组患儿的超氧化物歧化酶(Superoxide dismutase,SOD)、丙二醛(Malondialdehyde,MDA)、过氧化氢酶(Catalase enzymes,CAT)等过氧化物质水平。对比两组患儿的黄疸指数水平的变化并记录两组患儿的黄疸消退时间、出院时间。结果: 经过治疗两组患儿的IgA、IgG及MDA水平均显著升高,患儿的CAT和SOD显著降低,同时治疗后研究组患儿IgA、IgG及MDA水平均明显高于对照组患儿,CAT和SOD水平显著低于对照组,同时研究组治疗后较治疗前的IgA、IgG、CAT、SOD、MDA水平的变化的差异均显著高于对照组,差异均具有统计学意义(P<0.05);经过治疗后两组患儿的黄疸指数均明显降低,治疗后研究组患儿的黄疸指数显著低于对照组患儿,而研究组患儿治疗后黄疸指数水平降低差值也明显高于对照组,差异均具有统计学意义(P<0.05);研究组患儿治疗的总有效率显著高于对照组患儿,不良反应总发生率显著低于对照组,差异均具有统计学意义(P<0.05),差异均具有统计学意义(P<0.05)。结论: 早期间歇蓝光照射联合益生菌、黄疸茵陈颗粒治疗能够显著改善新生黄疸患儿的免疫功能状态,降低黄疸指数,减少患儿机体氧化应激损伤,促进患儿的恢复,具有较高的临床价值。

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关键词 ：新生儿黄疸, 益生菌, 黄疸茵陈颗粒, 黄疸指数

Abstract：Objective: To investigate the effects of early intermittent blue light irradiation combined with probiotics and jaundice Yinchen Granule on immune ability and jaundice index of neonatal jaundice.Methods: Totally 125 children with neonatal jaundice diagnosed and treated in our hospital from August 2017 to December 2020 were randomly divided into 63 cases in the study group and 62 cases in the control group. All children were treated with intermittent blue light irradiation. The patients in the study group were treated with probiotics and jaundice Yinchen Granule on the basis of phototherapy. The clinical effects of the two groups were evaluated and the total effective rate was calculated. The changes of immune function levels before and after treatment were compared and observed, mainly including immunoglobulin A (IGA) and immunoglobulin G (IgG). At the same time, the levels of superoxide dismutase (SOD), malondialdehyde (MDA) and catalase enzymes (CAT) were compared between the two groups. The changes of jaundice index in the two groups were compared, and the jaundice regression time and discharge time of the two groups were recorded.Results: After treatment, the levels of IgA, IgG and MDA in the two groups increased significantly, and the levels of CAT and SOD in the children decreased significantly. At the same time, the levels of IgA, IgG and MDA in the study group were significantly higher than those in the control group, and the levels of CAT and SOD were significantly lower than those in the control group. At the same time, the differences in the levels of IgA, IgG, CAT, SOD and MDA in the study group after treatment were significantly higher than those in the control group. The difference was statistically significant (P<0.05). After treatment, the jaundice index of children in the study group was significantly lower than that in the control group, while the jaundice index of children in the study group did not decrease after treatment, and the difference was significantly higher than that in the control group (P<0.05). The total effective rate of the study group was significantly higher than that of the control group, and the total incidence of adverse reactions was significantly lower than that of the control group (P<0.05).Conclusion: Early intermittent blue light irradiation combined with probiotics and jaundice Yinchen granule can significantly improve the immune function of newborn jaundice children, reduce jaundice index, reduce oxidative stress injury, and promote the recovery of children. It has high clinical value.

Key words： Jaundice of the newborn Probiotics Jaundice Yinchen granule Jaundice index

基金资助:2020年度省部共建放射医学与辐射防护国家重点实验室开放课题,(编号:K1202007)

通讯作者: 殷其改

引用本文:

侍海棠, 杨婷婷, 刘静, 冯红, 殷其改. 早期间歇蓝光照射联合益生菌黄疸茵陈颗粒治疗新生儿黄疸对免疫能力黄疸指数及临床疗效的影响[J]. 河北医学, 2022, 28(6): 924-929.
SHI Haitang, YANG Tingting, LIU Jing, et al. Effects of Early Intermittent Blue Light Irradiation Combined with Probiotics and Jaundice Yinchen Granule on Immune Competence Jaundice Index and Clinical Efficacy in the Treatment of Neonatal Jaundice. HeBei Med, 2022, 28(6): 924-929.

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http://www.hbyxzzs.cn/CN/10.3969/j.issn.1006-6233.2022.06.010 或 http://www.hbyxzzs.cn/CN/Y2022/V28/I6/924

[1] 彭程,侯新琳.《2018昆士兰产科与新生儿临床指南:新生儿黄疸》要点介绍[J].中华围产医学杂志,2020,23(4):285-288.
[2] Zhou S,Wu X,Ma A,et al.Analysis of therapeutic effect of intermittent and continuous phototherapy on neonatal hemolytic jaundice[J].Experimental and therapeutic medicine,2019,17(5):4007-4012.
[3] Tabatabaee R S,Golmohammadi H,Ahmadi S H.Easy diagnosis of jaundice:a smartphone-based nanosensor bioplatform using photoluminescent bacterial nanopaper for point-of-care diagnosis of hyperbilirubinemia[J].ACS sensors,2019,4(4):1063-1071.
[4] Beyoglu D,Idle J R.Metabolomic and lipidomic biomarkers for premalignant liver disease diagnosis and therapy[J].Metabolites,2020,10(2):50-57.
[5] Cayabyab R,Ramanathan R.High unbound bilirubin for age:a neurotoxin with major effects on the developing brain[J].Pediatric Research,2019,85(2):183-190.
[6] 冉珊,沈聃.早期不同蓝光照射方案治疗新生儿黄疸的效果及安全性观察[J].临床误诊误治,2019,32(1):96-100.
[7] Tremblay A,Xu X,Colee J,et al.Efficacy of a multi-strain probiotic formulation in pediatric populations:a comprehensive review of clinical studies[J].Nutrients,2021,13(6):1908-1914.
[8] 田艳华,高永伟,张永娇,等.蓝光间歇照射与蓝光持续照射辅助黄疸茵陈颗粒治疗新生儿黄疸疗效分析[J].山西医药杂志,2019,48(17):2152-2153.
[9] Hansen T W R,Wong R J,Stevenson D K.Molecular physiology and pathophysiology of bilirubin handling by the blood,liver,intestine,and brain in the newborn[J].Physiological Reviews,2020,100(3):1291-1346.
[10] 黄蓓,郑义雪,谢丽.微生态制剂联合蓝光照射对黄疸新生儿免疫功能及黄疸指数的影响[J].中国医学前沿杂志,2019,11(5):62-65.
[11] Tabrizi S J, Leavitt B R, Landwehrmeyer G B,et al.Targeting huntingtin expression in patients with huntington's disease[J].The New England Journal of Medicine,2019,380(24):2307-2312.
[12] 孔凡玲,胡绍举,刘宽,等.四磨汤联合水疗保健对新生儿黄疸免疫能力、黄疸指数及临床疗效的影响[J].中华中医药学刊,2018,36(7):1700-1703.