Abstract：Objective: To explore the effect of alteplase (rt-PA) combined with low-dose tirofiban on serum cytokines and the National Institutes of Health Stroke Scale (NIHSS) score of patients with acute ischemic stroke (AIS). Methods: According to the order of admission, 145 patients with AIS were divided into combination group (n=49), positive control group (n=48), and negative control group (n=48). Patients in the negative control group were given conventional treatment, patients in the positive control group were treated with rt-PA on the basis of conventional treatment, and patients in the combination group were treated with rt-PA combined with low-dose tirofiban on the basis of conventional treatment. The carotid intima-media thickness ( C-IMT), carotid plaque score (Crouse score), serum levels of high-sensitivity C-reactive protein (hs-CRP), interleukin 17 (IL-17) and vascular endothelial growth factor (VEGF), and safety indexes were compared among the 3 groups. The NIHSS and Activity of Daily Living Scale (ADL) were used to evaluate nerve function and self-care ability on the day of admission and after the end of treatment. The prognosis was judged based on the modified Rankin Scale (mRS) score at 3 months after the end of the treatment, namely, the score≤1 indicated good prognosis, and the score≥2 indicated poor prognosis. The good prognosis rate was compared among the groups. Results: After treatment, C-IMT, Crouse score, serum levels of hs-CRP, IL-17 and VEGF, and NIHSS score were significantly decreased, while ADL score was significantly increased in the 3 groups (P<0.05). The difference values of above indexes on the day of admission and after treatment in combination group were greater than those in positive control group and negative control group(P<0.05). There was no significant difference in adverse reactions among the three groups (P>0.05). The mRS score of combination group was significantly lower than that of positive control group or negative control group at 3 months after treatment, and the good prognosis rate was significantly higher than that in positive control group and negative control group(P<0.05). Conclusion: The treatment of rt-PA combined with low-dose tirofiban for AIS can effectively reduce C-IMT, Crouse score, serum levels of hs-CRP, IL-1 and VEGF, and NIHSS score, and increase ADL score, thus improving the prognosis.
符金岛, 杨辉, 王英霞, 徐晶. 阿替普酶联合小剂量替罗非班对急性脑梗死患者血清细胞因子NIHSS评分的影响[J]. 河北医学, 2022, 28(6): 1041-1046.
FU Jindao, YANG Hui, WANG Yingxia, et al. Effect of Alteplase Combined with Low-Dose Tirofiban on Serum Cytokines and NIHSS Score of Patients with Acute Ischemic Stroke. HeBei Med, 2022, 28(6): 1041-1046.
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2022, Vol. 28 
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