Abstract：Objective: To explore the application value of CT-guided Hook-wire localization combined with thoracoscopic surgery in patients with early stage lung cancer. Methods: 60 patients with early-stage lung cancer from January 2018 to January 2021 were selected and grouped according to the random number table method, with 30 patients in each group. The control group was treated with conventional thoracoscopic surgery, and the study group was treated with CT guided hook wire positioning combined with thoracoscopic surgery. The surgical conditions, positive rate of incision margin, trauma stress indexes [interleukin-6 (IL-6), interleukin-8 (IL-8), cortisol (COR), C-reactive protein (CRP)], cardiopulmonary function [stroke volume (SV), left ventricular ejection fraction (LVEF), forced vital capacity (FVC), maximum ventilation volume per minute (MVV)] were compared between the two groups The levels of tumor related growth factors [vascular endothelial growth factor-C (VEGF-C), tumor specific growth factor (TSGF), epidermal growth factor receptor (EGFR)], the quality of life scale for lung cancer patients (FACT-L) and the incidence of complications. Results: Compared with the control group (161.55 ± 40.31) ml, (157.22 ± 35.21) min, (4.53 ± 1.26) d, (15.27 ± 4.02) d, (6.90 ± 0.46), the study group had less intraoperative bleeding (108.67 ± 26.83) ml, operation time (136.43 ± 30.19) min, thoracic drainage time (2.82 ± 0.90) d, hospital stay (11.34 ± 2.58) d, and more lymph node dissections (7.45 ± 0.50) (P<0.05). There was no significant difference in the positive rate of cutting edge between the two groups (P>0.05); Compared with the control group, the levels of serum IL-6, IL-8, cor and CRP in the study group were lower on the 1st, 3rd and 5th day after operation (P<0.05); SV, LVEF, FVC and MVV in the two groups 1 week and 1 month after operation were higher than those before operation, and compared with the control group, the study group was higher, the serum VEGF-C, TSGF and EGFR were lower than those before operation, and compared with the control group, the study group was lower (P<0.05); Three months after operation, the scores of physiological status, social / family status, relationship with doctors, emotional status, functional status and additional attention of the two groups were higher than those before operation, and the study group was higher than that of the control group (P<0.05); Compared with 26.67% (8 / 30) of the control group, the incidence of complications in the study group was 6.67% (2 / 30) (P<0.05). Conclusion: CT guided hook wire positioning combined with thoracoscopic surgery in the treatment of patients with early lung cancer can significantly optimize the operation, inhibit tumor growth, avoid positive margin, promote the recovery of cardiopulmonary function, reduce complications and improve the quality of life.
孔劲松. CT引导下Hook-wire定位配合胸腔镜手术在早期肺癌患者中的应用[J]. 河北医学, 2022, 28(5): 823-828.
KONG Jinsong. Application of CT-guided Hook-wire Localization Combined with Thoracoscopic Surgery in Patients with Early Lung Cancer. HeBei Med, 2022, 28(5): 823-828.
2022, Vol. 28 
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