Abstract：Objective: To analyze the relationship between type 2 diabetic nephropathy and serum Netrin-1 level, and to provide a new idea for risk prediction of type 2 diabetic nephropathy. Methods: 180 patients with type 2 diabetes admitted to our hospital from August 2019 to August 2021 were divided into normal albuminuria group (UAER < 30 mg/gCr), microalbuminuria group (UAER 30~<300 mg/gCr) and massive albuminuria group (UAER≥300 mg/gCr) according to UAER. The age, body mass index (BMI) and serum Netrin levels of the three groups were compared, and Logistic multivariate regression analysis was used to summarize the related factors affecting UAER in patients with type 2 diabetes mellitus. Results: Logistic regression analysis showed that the course of disease ≥5 years, systolic blood pressure ≥120 mmHg, diastolic blood pressure ≥90mmHg, FPG≥6.1 mmol/L and Netrin-1≥300 ng/L were independent risk factors for UAER in patients with type 2 diabetes mellitus (P<0.05). Serum Netrin-1 in normal albuminuria group, microalbuminuria group and massive albuminuria group increased in turn, and the difference between the groups was statistically significant (P<0.05). Pearson correlation analysis showed that serum Netrin-1 was positively correlated with UAER (r=0.616, P<0.05). Conclusion: The increase of serum Netrin-1 is one of the important factors in the occurrence and development of diabetic nephropathy in patients with type 2 diabetes mellitus, and the increase of Netrin-1 is closely related to the increase of UAER.
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2022, Vol. 28 
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