Changes in the Levels of Eosinophil Chemokines and Inflammatory Mediators During Acute Exacerbations of Chronic Bronchitis in the Elderly and Their Clinical Significance
XIE Mingying, YANG Yuanrui, CAI Lingqin, et al
The General Hospital of the Western Area Command, Sichuan Chengdu 610083, China
Abstract：Objective: To explore the changes and clinical significance of eosinophil chemokines and inflammatory mediators in elderly patients with acute attack of chronic bronchitis. Methods: A total of 186 elderly patients with chronic bronchitis (study group) and 80 healthy elderly people (control group) were selected between August 2020 and September 2021. The levels of eosinophil chemokines and inflammatory mediators in the two groups were tested and compared. Results:The levels of eosinophil chemokines and monocyte chemotactic protein-1 (MCP-1) in study group were higher than those in the control group (P<0.05). The levels of tumor necrosis factor-α (TNF-α), high-sensitivity C-reactive protein (hs-CRP) and procalcitonin (PCT) in study group were higher than those in the control group (P<0.05). The levels of eotaxin and MCP-1 in elderly patients with acute attack of chronic bronchitis were higher than those in chronic protracted stage and remission stage (P<0.05). The levels of eosinophil chemokines and MCP-1 in chronic protracted stage were higher than those in remission stage (P<0.05). The levels of TNF-α, hs-CRP and PCT in elderly patients with acute attack of chronic bronchitis were higher than those in chronic protracted stage and remission stage (P<0.05). Conclusion: The detection of Eotaxin, MCP-1, TNF-α, hs-CRP and PCT has important indications in elderly patients with acute attack of chronic bronchitis.
谢明英, 杨源瑞, 蔡羚琴, 李龙心, 熊覃. 老年慢性支气管炎急性发作期嗜酸细胞趋化因子及炎症介质水平变化及临床意义[J]. 河北医学, 2022, 28(5): 759-762.
XIE Mingying, YANG Yuanrui, CAI Lingqin, et al. Changes in the Levels of Eosinophil Chemokines and Inflammatory Mediators During Acute Exacerbations of Chronic Bronchitis in the Elderly and Their Clinical Significance. HeBei Med, 2022, 28(5): 759-762.
[1] 张梅香.三拗汤合止嗽散治疗慢性支气管炎急性加重期咳嗽的疗效观察[J].山西医药杂志,2021,50(5):835~837. [2] Lu Y,Wang X,Zhao J.Effects of azithromycin on treating chronic obstructive pulmonary disease with acute exacerbation of chronic bronchitis in the stable phase[J].Am Transl Res,2021,13(6):7370~7375. [3] Valipour A,Fernandez-Bussy S,Ing AJ,et al.Bronchial rheoplasty for treatment of chronic bronchitis.Twelve-month results from a multicenter clinical trial[J].Am Respir Crit Care Med,2020,202(5):681~689. [4] Figgs LW.Elevated chronic bronchitis diagnosis risk among women in a local emergency department patient population associated with the 2012 heatwave and drought in Douglas county,NE USA[J].Heart Lung,2020,49(6):934~939. [5] Andelid K,Ost K,Andersson A,et al.Lung macrophages drive mucus production and steroid-resistant inflammation in chronic bronchitis[J].Respir Res,2021,22(1):172~175. [6] Singh D,Bassi M,Balzano D,et al.COPD patients with chronic bronchitis and higher sputum eosinophil counts show increased type-2 and PDE4 gene expression in sputum[J].Cell Mol Med,2021,25(2):905~918. [7] 闫振宇.慢性支气管炎的中西医护理效果及对患者呼吸功能的影响[J].西部中医药,2021,34(1):121~124. [8] 中华医学会.急性气管-支气管炎基层诊疗指南(2018年)[J].中华全科医师杂志,2019,18(4):314~317. [9] 刘翠霞.温肺饮对慢性支气管炎急性发作患者血清IL-2,IL-33,PCT水平的影响[J].陕西中医,2018,39(3):304~306.
2022, Vol. 28 
冀公网安备13080202000677号