急性颅脑损伤患者血清中HMGB1 Fas表达水平与术后迟发性颅内血肿的关系

doi:10.3969/j.issn.1006-6233.2022.04.019

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摘要 目的:探讨急性颅脑损伤患者血清高迁移率族蛋白 B1(HMGB1)、Fas表达水平与术后迟发性颅内血肿(Delayed intracranial hematoma,DTIH)的关系。方法:回顾性选取我院2018年12月至2020年12月收治的181例急性颅脑损伤患者作为研究对象,根据术后CT复查将入组患者分为DTIH组(n=92例)与非DTIH组(n=89例),比较两组术后血清HMGB1、Fas水平及其他临床资料,并通过Logistic回归模型分析血清HMGB1、Fas水平与DTIH的关系。结果:DTIH组与非DTIH组相比,血清HMGB1、Fas差异有统计学意义(P<0.05);DTIH组格拉斯哥昏迷指数(GCS)评分低于非DTIH组(P<0.05),血浆凝血酶时间(TT)高于非DTIH组(P<0.05);经Logistic回归分析显示血清HMGB1、Fas与TT、GCS评分是急性颅脑损伤患者术后DTIH的影响因素(P<0.05)。结论:急性颅脑损伤患者术后DTIH发生的情况较为严重,可能与血清HMGB1、Fas等因素有关,临床可根据相关因素的监测,为疾病诊治及预防提供有效依据。

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	王瑜玥
	范云飞
	杨晓鲲
	王龙海

关键词 ：急性颅脑损伤, 迟发性颅内血肿, 血清高迁移率族蛋白 B1, Fas

Abstract：Objective: To investigate the relationship betweenserum levels of high mobility group box 1 (HMGB1) and Fas and postoperative delayed traumatic intracranial hematoma (DTIH) in patients with acute craniocerebral injury. Methods: A total of 181 patients with acute craniocerebral injury admitted to the hospital between December 2018 and December 2020 were selected as the research subjects. According to postoperative CT examination results, the patients enrolled were divided into DTIH group (n=92) and non-DTIH group (n=89). Postoperative serum levels of HMGB1 and Fas, and other clinical data were compared between the two groups. The relationship between serum levels of HMGB1 and Fas and DTIH was analyzed using Logistic regression model.Results: There were statistically significant differences in serum HMGB1 and Fas between the two groups (P<0.05). The Glasgow Coma Scale (GCS) score of DTIH group was lower than that of the non-DTIH group (P<0.05), and and thrombin time (TT) was longer than that of the non-DTIH group (P<0.05). Logistic regression analysis showed that serum HMGB1, Fas, TTand GCS scorewere influencing factors of postoperative DTIH in patients with acute craniocerebral injury (P<0.05).Conclusion: The occurrence of DTIH in patients with acute craniocerebral injury may be related to serum HMGB1 and Fas. Clinical monitoring of related factors can provide an effective basis for disease diagnosis, treatment and prevention.

Key words： Acute craniocerebral injury Delayed traumatic intracranial hematoma Serum high mobility group box 1 Fas

基金资助:四川省达州市医学科研课题,(编号:2018010)

通讯作者: 杨晓鲲

引用本文:

王瑜玥, 范云飞, 杨晓鲲, 王龙海. 急性颅脑损伤患者血清中HMGB1 Fas表达水平与术后迟发性颅内血肿的关系[J]. 河北医学, 2022, 28(4): 624-627.
WANG Yuyue, FAN Yunfei, YANG Xiaokun, et al. Relationship Between HMGB1 and Fas Expression Levels in Serum ofPatients with Acute Craniocerebral Injury and Postoperative Delayed Intracranial Hematoma. HeBei Med, 2022, 28(4): 624-627.

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http://www.hbyxzzs.cn/CN/10.3969/j.issn.1006-6233.2022.04.019 或 http://www.hbyxzzs.cn/CN/Y2022/V28/I4/624

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