妊娠期高血压患者PECAM-1 LRRFIP PagT表达及预测子痫前期的ROC分析

doi:10.3969/j.issn.1006-6233.2022.04.012

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摘要 目的:探讨妊娠期高血压(GH)患者血小板内皮细胞黏附分子1(PECAM-1)、富亮氨酸重复序列相互作用蛋白(LRRFIP)、血小板聚集率(PagT)表达及预测子痫前期(PE)的价值。方法:选取2018年4月至2021年2月我院收治的93例GH患者,根据病情进展情况分为子痫组(n=22)、PE组(n=31)、GH组(n=40),并选取同期正常孕妇35例作为对照组。比较各组基线资料、PECAM-1、LRRFIP、PagT、收缩压、舒张压、尿蛋白定量,应用Pearson分析PECAM-1、LRRFIP、PagT与收缩压、舒张压、尿蛋白定量关系,采用多因素Logistic回归方程分析PE及子痫的相关影响因素,采用受试者工作特征曲线(ROC)及ROC下面积(AUC)分析PECAM-1、LRRFIP、PagT预测PE及子痫的价值。结果:PECAM-1:子痫组<PE组<GH组<对照组,LRRFIP、PagT、收缩压、舒张压、尿蛋白定量:子痫组>PE组>GH组>对照组(P<0.05);PECAM-1与收缩压、舒张压、尿蛋白定量呈负相关,LRRFIP、PagT与收缩压、舒张压、尿蛋白定量呈正相关(P<0.05);将收缩压、舒张压、尿蛋白定量控制后,PECAM-1、LRRFIP、PagT仍与PE及子痫的发生相关(P<0.05);预测PE的AUC:PECAM-1为0.723,LRRFIP为0.761,PagT为0.682,三者联合为0.804;预测子痫的AUC:PECAM-1为0.777,LRRFIP为0.779,PagT为0.735,三者联合为0.850。结论:GH患者PECAM-1、LRRFIP、PagT表达与PE、子痫的发生有关,联合检测可作为预测PE及子痫的有效方案,为临床提供参考。

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	李燕茹

关键词 ：妊娠期高血压, 血小板内皮细胞黏附分子1, 富亮氨酸重复序列相互作用蛋白, 血小板聚集率, 子痫前期, 子痫

Abstract：Objective: To investigate the expression of platelet endothelial cell adhesion molecule 1 (PECAM-1), leucine-rich repeat interacting protein (LRRFIP), and platelet aggregation rate (PagT), and to investigate the value in predicting preeclampsia(PE), in patients with Gestational hypertension (GH). Methods: A total of 93 GH patients admitted to our hospital from April 2018 to February 2021 were selected and divided into eclampsia group (n=22), PE group (n=31), and GH group (n=40) according to the progress of the disease. And 35 healthy pregnant women were made the control group. The baseline data of each group, PECAM-1, LRRFIP, PagT, systolic blood pressure, diastolic blood pressure, and urine protein quantification were compared; Pearson was used to analyze the quantitative relationship between PECAM-1, LRRFIP, PagT and systolic blood pressure, diastolic blood pressure, and urine protein; multi-factor Logistic regression equation was used to analyze the related factors of PE and eclampsia; the receiver operating characteristic curve (ROC) and area under ROC (AUC) were used to analyze the value of PECAM-1, LRRFIP, and PagT in predicting PE and eclampsia. Results: PECAM-1: eclampsia group<PE group<GH group<control group; LRRFIP, PagT, systolic blood pressure, diastolic blood pressure, urine protein quantification: eclampsia group>PE group>GH group>control group (P<0.05); PECAM-1 is negatively correlated with systolic blood pressure, diastolic blood pressure, and urine protein quantification. LRRFIP and PagT are positively correlated with systolic blood pressure, diastolic blood pressure, and urine protein quantification (P<0.05). After the systolic blood pressure, diastolic blood pressure, and urine protein quantification are controlled, PECAM-1, LRRFIP, PagT are still related to the occurrence of PE and eclampsia (P<0.05). Predictors of AUC of PE : PECAM-1 is 0.723, LRRFIP is 0.761, PagT is 0.682, the combination of the three is 0.804; predictors of AUC of epilepsy: PECAM-1 is 0.777, LRRFIP is 0.779, PagT is 0.735, and the combination of the three is 0.850. Conclusion: The expressions of PECAM-1, LRRFIP and PagT in GH patients are related to the occurrence of PE and eclampsia. Combined detection can be used as an effective regimen to predict PE and eclampsia, and provide references for clinical monitoring and intervention.

Key words： Gestational hypertension PECAM-1 LRRFIP PagT Preeclampsia Eclampsia

基金资助:云南省科技厅课题计划,(编号:202001BA070001-014)

引用本文:

李燕茹. 妊娠期高血压患者PECAM-1 LRRFIP PagT表达及预测子痫前期的ROC分析[J]. 河北医学, 2022, 28(4): 589-593.
LI Yanru. The Expression of PECAM-1 LRRFIP PagT in Patients with Gestational Hypertension and the ROC Analysis of Predicting Preeclampsia. HeBei Med, 2022, 28(4): 589-593.

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http://www.hbyxzzs.cn/CN/10.3969/j.issn.1006-6233.2022.04.012 或 http://www.hbyxzzs.cn/CN/Y2022/V28/I4/589

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