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河北医学  2022, Vol. 28 Issue (4): 550-553    DOI: 10.3969/j.issn.1006-6233.2022.04.05
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人参-麦冬治疗抗肿瘤药物致心脏毒性作用机制探讨
杨梦霞1,2, 芦殿荣1, 朱世杰1, 王宁军1
1.中国中医科学院望京医院, 北京 100102
2.北京中医药大学, 北京 100029
The Mechanism of "Renshen-Maidong" in the Treatment of Antineoplastic Drug-Induced Cardiotoxicity
YANG Mengxia, et al
Wangjing Hospital, China Academy of Chinese Medical Sciences, Beijing 100102, China
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摘要 目的:运用网络药理学方法研究“人参-麦冬”药对治疗抗肿瘤药物致心脏毒性(Antineoplastic Drug-Induced Cardiotoxicity,ADIC)作用机制。方法:利用TCMSP、TCMID和TCM Database@Taiwan数据库检索药物主要有效成分,利用Swiss Target Prediction数据库筛选药物相关靶点,通过GengCards和DisGeNet数据库收集ADIC相关疾病基因,并将药物靶点和疾病基因进行韦恩分析,并在DAVID数据库中进行富集分析,通过Cytoscape软件构建“中药-有效成分-靶点-通路”的多层次网络,筛选出核心基因。结果:“人参-麦冬”主要有效成分有42个,包含769个靶点。ADIC基因有354个,其中102个是人参-麦冬治疗ADIC的潜在靶点。通过富集分析发现“人参-麦冬”治疗ADIC是通过VEGF、TNF及ErbB等信号通路发挥心脏保护作用。“人参-麦冬”治疗ADIC的重要基因为SRC、CASP3、STAT3和MAPK1/14等。结论:通过网络药理学方法构建“中药-有效成分-靶点-通路”网络,发现“人参-麦冬”治疗ADIC的作用机制涉及多靶点、多通路,可能与抗氧化应激、抗炎、抗细胞凋亡及促血管生成等相关。
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关键词 “人参-麦冬”抗肿瘤药物致心脏毒性网络药理学    
AbstractObjective: To investigate the mechanism of "Renshen-Maidong" drug pair in the treatment of antineoplastic drug-induced cardiotoxicity (ADIC) by network pharmacology. Methods: TCMSP, TCMID and TCM Database@Taiwan databases were used to screen the main active ingredients of the drugs. Swiss Target database was used to search the drugs-related targets. GengCards and DisGeNet databases were used to collect the ADIC-related disease genes. Drug targets and disease genes were subjected to Venny analysis, and enrichment analysis was performed in DAVID database. The multi-level network "herbs-effective components-targets-pathways" was constructed by Cytoscape software, and the core genes were screened out.Results: There were 42 main active ingredients in "Renshen-Maidong", which contained 769 targets, and 354 ADIC genes, of which 102 were potential targets of "Renshen-Maidong" for the treatment of ADIC. Through enrichment analysis, it was found that "Renshen-Maidong" exerted cardioprotective effects through VEGF, TNF, ErbB and other signaling pathways in the treatment of ADIC. The important genes of "Renshen-Maidong" in treating ADIC are SRC, CASP3, STAT3, and MAPK1/14 and so on.Conclusion: We constructed the network "herbs-effective components-targets-pathways" through network pharmacology, and found that the mechanism of action of "Renshen-Maidong" in treating ADIC involves multiple targets and pathways, which may be related to antioxidant stress, anti inflammation, anti apoptosis, and promoting angiogenesis, etc.
Key words"Renshen-Maidong" drug pair    ADIC    Network pharmacology
    
基金资助:国家自然科学基金面上项目,(编号:81973640)
通讯作者: 芦殿荣   
引用本文:   
杨梦霞, 芦殿荣, 朱世杰, 王宁军. 人参-麦冬治疗抗肿瘤药物致心脏毒性作用机制探讨[J]. 河北医学, 2022, 28(4): 550-553.
YANG Mengxia, et al. The Mechanism of "Renshen-Maidong" in the Treatment of Antineoplastic Drug-Induced Cardiotoxicity. HeBei Med, 2022, 28(4): 550-553.
链接本文:  
http://www.hbyxzzs.cn/CN/10.3969/j.issn.1006-6233.2022.04.05     或     http://www.hbyxzzs.cn/CN/Y2022/V28/I4/550
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