Clinical Application of Treprostinil in Combination with Salmeterol and Ficasone in Patients with Chronic Obstructive Pulmonary Disease and Severe Pulmonary Hypertension
HU Xiaochun, LIU Shiwu, TENG Lifeng, et al
Hainan Provincial People's Hospital, Hainan Haikou 570311, China
Abstract：Objective: To explore the clinical effect of treprostinil in combination with salmeterol on patients with chronic obstructive pulmonary disease (COPD) and severe pulmonary hypertension (PAH). Methods: A total of 147 COPD patients with severe PAH admitted to our hospital from January 2018 to January 2021 were selected for the study. The random number table method was used for simple random grouping, and they were divided into two groups: study group and control group, with 77 cases in study group. In the control group, 70 cases were treated with Trepronil injection. The study group was combined with salmeterol and ticasone powder on this basis. Both groups were treated for 21 days. The clinical efficacy, pulmonary function parameters [1st second expiratory volume (FEV1) as a percentage of predicted value (FEV1%pred) and 1st second expiratory volume to expiratory spirometry ratio (FEV1/FVC)], plasma levels of nitric oxide (NO), endothelin (ET-1), soluble guanylate cyclase (cGMP), adenylate cyclase (cAMP), serum inflammatory factors [Apelin, tumour necrosis factor-α (TNF-α), hypersensitive C-reactive protein (hs-CRP)], and the occurrence of adverse reactions between the two groups were compared. Results: The total effective rates of the study group and the control group were 93.51% and 78.57% respectively (P＜0.05); the difference in FEV1/FVC and FEV1%pre, NO, ET-1, cGMP, cAMP, hs-CRP, TNF-αand Apelin before and after treatment in the study group was higher than the difference before and after treatment in the control group (P<0.05); there was no significant difference in adverse reactions between the two groups (P>0.05). Conclusion: Treprostinil in combination with salmeterol and ticassone has significant effects in the treatment of chronic obstructive pulmonary disease complicated with severe pulmonary hypertension. It has great advantages in improving lung function and reducing inflammation, and is suitable for popularization and application.
胡小春, 刘时武, 滕丽峰, 叶丛, 张如俊. 曲前列尼尔联合沙美特罗替卡松对慢性阻塞性肺疾病合并重症肺动脉高压患者的临床应用分析[J]. 河北医学, 2022, 28(3): 513-518.
HU Xiaochun, LIU Shiwu, TENG Lifeng, et al. Clinical Application of Treprostinil in Combination with Salmeterol and Ficasone in Patients with Chronic Obstructive Pulmonary Disease and Severe Pulmonary Hypertension. HeBei Med, 2022, 28(3): 513-518.
2022, Vol. 28 
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