低分子肝素联合阿司匹林治疗妊娠期高血压对氧化应激子宫动脉血流TEG参数及妊娠结局的影响

doi:10.3969/j.issn.1006-6233.2022.03.032

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摘要 目的:探索低分子肝素联合阿司匹林治疗妊娠期高血压对氧化应激、子宫动脉血流、TEG参数及妊娠结局的影响。方法:前瞻性选取的126例妊娠期高血压患者在2019年2月至2021年2月期间收治,采用简单随机分组方法分为两组,对照组64例进行常规用药治疗,观察组62例进行低分子肝素联合阿司匹林治疗,并比较治疗后TEG参数、子宫动脉血流、氧化应激、妊娠结局。结果:观察组治疗后30d的R(6.95±1.22)min、K(2.15±0.11)min、α-Angle(72.12±4.63)度、MA(66.96±3.32)mm参数改善情况优于对照组(P<0.05),且观察组治疗后各时间段LPO、GSH-PX、Hcy、SOD、PI、RI、S/D稳定情况优于对照组(P<0.05)。同时观察组剖宫产12.90%、产后出血3.23%、胎盘早剥1.61%、新生儿窒息0.00%、早产3.23%、胎儿窘迫率1.61%低于对照组剖宫产32.81%、产后出血18.75%、胎盘早剥10.94%、新生儿窒息9.38%、早产15.63%、胎儿窘迫率12.50%(P<0.05)。结论:对妊娠期高血压患者实施低分子肝素联合阿司匹林治疗,可改善氧化应激反应,稳定子宫动脉血流,减少母婴不良妊娠结局发生。

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	肖瑾
	杜云
	贺同强
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关键词 ：妊高症, 低分子肝素, 阿司匹林, 子宫动脉血流, 氧化应激, 妊娠结局

Abstract：Objective: To explore the effect of low molecular heparin combined with aspirin in the treatment of pregnancy-induced hypertension on oxidative stress, uterine artery blood flow, TEG parameters and pregnancy outcome. Methods: A total of 126 patients with pregnancy-induced hypertension admitted between February 2019 and February 2021 were divided into 2 groups using a simple randomized grouping method, 64 in the control group were treated with conventional medication and 62 in the observation group were treated with low molecular heparin combined with aspirin, and the two groups were compared for TEG parameters, uterine artery blood flow, oxidative stress, and pregnancy outcome after treatment. Results: The R (6.95±1.22) min, K (2.15±0.11) min and α-Angle (72.12±4.63)°and MA (66.96 ± 3.32) mm parameters in the observation group was better than in the control group (P<0.05), and the stability of LPO, GSH-Px, Hcy, SOD, PI, RI and S/D in the observation group was better than in the control group (P<0.05). At the same time, in the observation group, 12.90% cesarean delivery, 3.23% postpartum haemorrhage, 1.61% placental abruption, 0.00% neonatal asphyxia, 3.23% preterm delivery and 1.61% fetal distress rate were lower than the control group with 32.81% cesarean delivery, 18.75% postpartum haemorrhage, 10.94% placental abruption, 9.38% neonatal asphyxia, 15.63% preterm delivery and 12.50% fetal distress rate (P<0.05). Conclusion: The treatment of low molecular heparin combined with aspirin in patients with pregnancy-induced hypertension can improve the oxidative stress response, stabilize the uterine artery blood flow, and reduce the occurrence of adverse pregnancy outcomes.

Key words： Pregnancy-induced hypertension Low molecular heparin Aspirin Uterine artery blood flow Oxidative stress Pregnancy outcome

基金资助:陕西省科学技术厅重点研发计划项目,(编号:2018SF-078)

通讯作者: 杜云

引用本文:

肖瑾, 杜云, 贺同强, 薛倩. 低分子肝素联合阿司匹林治疗妊娠期高血压对氧化应激子宫动脉血流TEG参数及妊娠结局的影响[J]. 河北医学, 2022, 28(3): 503-507.
XIAO Jin, DU Yun, HE Tongqiang, et al. Effects of Low Molecular Heparin Combined with Aspirin on Oxidative Stress, Uterine Artery Blood Flow TEG Parameters and Pregnancy Outcome in the Treatment of Pregnancy-Induced Hypertension. HeBei Med, 2022, 28(3): 503-507.

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http://www.hbyxzzs.cn/CN/10.3969/j.issn.1006-6233.2022.03.032 或 http://www.hbyxzzs.cn/CN/Y2022/V28/I3/503

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