Abstract：Objective: To analyze the therapeutic effect of omeprazole combined with intestinal microecological regulator on neonatal necrotizing enterocolitis (NEC). Methods: Children with NEC who came to the hospital for treatment between January 2016 and July 2021 were selected as the research subjects, and they were divided into observation group and control group according to the principles of non-randomized clinical concurrent control and voluntariness of family members. The children in the control group were treated with intestinal microecological regulator, and the children in the observation group were given omeprazole on the basis of the control group. The relief time of clinical symptoms and clinical efficacy after 3d of treatment were compared between the two groups of children. The intestinal flora, immune function and imaging manifestations of the two groups were compared before and after treatment. Results: The diarrhea relief time, abdominal distension relief time and relief time of irregular bowel movement during treatment of observation group were shorter than those of control group, and the clinical efficacy after 3 d of treatment was better than that of control group (all P<0.05). The intestinal flora counts (total number of intestinal bacteria, total number of cocci, total number of bacilli), proportion of CD4+ and CD4+/CD8+ ratio after 3 d of treatment in the two groups were increased compared with those before treatment, and the differences before and after treatment were greater in observation group than those in control group (all P<0.05). The levels of serum CRP and PCT in the two groups were lower after 3d of treatment than those before treatment, and the differences before and after treatment between observation group and control group were significant (all P<0.05). The improvement ratios of intestinal wall thickening and fixed intestinal loop shadow before and after treatment in observation group were higher than those in control group (all P<0.05), but there was no statistical significance in the improvement ratio of portal venous gas between the two groups before and after treatment (P>0.05). Conclusion: Omeprazole combined with intestinal microecological regulator can effectively improve the immunity, relieve the inflammatory response, shorten the course of disease, and promote the rehabilitation of children with NEC.
杨雪, 赵旭晶. 奥美拉唑联合肠道微生态调节剂治疗新生儿坏死性小肠结肠炎的疗效分析[J]. 河北医学, 2022, 28(3): 472-477.
YANG Xue, ZHAO Xujing. An Analysis of the Efficacy of Omeprazole Combined with Intestinal Microecological Regulator in the Treatment of Neonatal Necrotizing Enterocolitis. HeBei Med, 2022, 28(3): 472-477.
2022, Vol. 28 
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