Curative Effect of Cisplatin Hyperthermic Intraperitoneal Chemotherapy Combined with Intravenous Chemotherapy in the Treatment of Gastric Cancer and Its Influence on Serum IGF-1 VEGF and EGFR Levels
MIN Tao, LIU Lihua, et al
Mianyang Central Hospital ,School of Medicine, University of Electronic Science and Technology of China / Mianyang Hospital, Sichuan Mianyang 621000, China
Abstract：Objective: To investigate the curative effect of cisplatin hyperthermic intraperitoneal chemotherapy (HIPEC) combined with intravenous chemotherapy in the treatment of gastric cancer, and its influence on serum insulin-like growth factor-1 (IGF-1), vascular endothelial growth factor (VEGF) and epidermal growth factor receptor (EGFR) levels. Methods: Totally 112 patients with gastric cancer were divided into observation group (n=60) and control group (n=52) according to the principle of voluntariness. The observation group was given cisplatin HIPEC combined with intravenous chemotherapy, while the control group was given intravenous chemotherapy alone. The short-term curative effect, quality of life and adverse reactions were compared between the two groups. The levels of serum IGF-1, VEGF and EGFR were determined before and after treatment. Results: The short-term total response rate in the observation group was 61.67%, which was significantly higher than the control group at 36.54%(P<0.05). The incidence of nausea, vomiting and bone marrow suppression in the observation group was slightly higher than that in the control group, with statistical differences (P<0.05). After treatment, serum IGF-1, VEGF and EGFR levels were significantly reduced in the two groups, and the difference of each index in the observation group was greater than that in the control group. (P<0.05). Conclusion: Cisplatin HIPEC in combination with intravenous chemotherapy can achieve better short-term curative effect than intravenous chemotherapy alone in the treatment of gastric cancer. The former can significantly improve serum IGF-1, VEGF and EGFR levels of patients without increasing side effects.
闵涛, 刘丽华, 李鑫月, 张思奇. 顺铂腹腔热灌注联合静脉化疗治疗胃癌疗效及对血清IGF-1 VEGF EGFR水平的影响[J]. 河北医学, 2022, 28(3): 451-456.
MIN Tao, LIU Lihua, et al. Curative Effect of Cisplatin Hyperthermic Intraperitoneal Chemotherapy Combined with Intravenous Chemotherapy in the Treatment of Gastric Cancer and Its Influence on Serum IGF-1 VEGF and EGFR Levels. HeBei Med, 2022, 28(3): 451-456.
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2022, Vol. 28 
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