Analysis of Clinical Characteristics and Factors Influencing the Long-Term Prognosis of Patients with Premature Coronary Artery Disease by Gender After Percutaneous Coronary Intervention
HUO Mingyan, ZHANG Na, LIU Yahuan, et al
The Affiliated Hospital of Chengde Medical University, Hebei Chengde 067000, China
Abstract：Objective: To investigate the clinical characteristics of patients with premature coronary artery disease (PCAD) by gender after percutaneous coronary intervention (PCI), to analyze factors influencing long-term prognosis, and to provide guidance for the treatment of patients. Methods: Totally 150 patients admitted to the Affiliated Hospital of Chengde Medical University from February 2018 to February 2020 who were diagnosed with coronary heart disease and underwent percutaneous coronary intervention were selected as research subjects and divided into male and female groups. The clinical data, interventional treatment data and follow-up of all patients were recorded, the clinical characteristics of premature coronary artery disease (PCAD) were analyzed, and the influencing factors of long-term prognosis were further explored. Results: In the male group, the age of onset was younger (P＜0.01), the proportion of smoking was higher (P＜0.05), the BMI index was higher, and the proportion of ST-segment elevation myocardial infarction (P＜0.05), the glomerular filtration rate (P＜0.01) ), left ventricular end-diastolic diameter (P<0.01), and hyperlipidemia (P<0.05) were all high, while the incidence of hypertension (P<0.05) and diabetes (P<0.05) was low, and the incidence of previous stroke was high. (P<0.05), which was statistically significant after statistical analysis. However, there was no statistical difference in the left ventricular ejection fraction and GRACE score between the two groups (P>0.05); the incidence of adverse events between the two groups ( including MACCE, death, myocardial infarction, revascularization, and stroke) showed no significant difference (P>0.05), but the bleeding rate in the female group was significantly higher than that in the male group. Bleeding differences are mainly manifested in the distinction between BARC levels 1-2. Statistical analysis showed statistical difference (P<0.05). Conclusion: The clinical characteristics of patients with premature coronary artery disease of different genders after percutaneous coronary intervention are different. Individualized treatment regimens should be followed for patients of different genders, and patients should be encouraged to develop a good life style and reduce their stress. Metabolic abnormalities are expected to reduce the incidence of premature coronary artery disease. Secondly, women and myocardial infarction are the influencing factors of postoperative bleeding after PCI. Identifying these postoperative factors can provide certain guidance for the later treatment of patients.
霍明艳, 张娜, 刘环亚, 周青云, 王珠秀. 经皮冠状动脉介入治疗术后不同性别早发冠心病患者的临床特点及远期预后的影响因素分析[J]. 河北医学, 2022, 28(3): 412-417.
HUO Mingyan, ZHANG Na, LIU Yahuan, et al. Analysis of Clinical Characteristics and Factors Influencing the Long-Term Prognosis of Patients with Premature Coronary Artery Disease by Gender After Percutaneous Coronary Intervention. HeBei Med, 2022, 28(3): 412-417.
[1] 唐晓芳,宋莹,许晶晶,等.经皮冠状动脉介入治疗术后不同性别早发冠心病患者的临床特点及远期预后的影响因素[J].中华心血管病杂志,2019,47(10):798~805. [2] 周亮,叶显华,鲁明,等.早发冠心病患者冠脉病变特征及介入术后预后随访分析[J].浙江临床医学,2018,20(2):223~225. [3] 蒲阳,杨军.阿托伐他汀钙对急性冠状动脉综合征患者PCI术后心肌微循环及内皮细胞微粒和C反应蛋白的影响[J].中国医药导报,2019,45(11):54~57. [4] 刘博江,王赟赟,吴鹏,等.急诊经皮冠状动脉介入治疗术中应用血栓抽吸联合替罗非班治疗对炎性反应因子的影响[J].武警医学,2019,30(4):291~294. [5] 刘凤,徐芬,任静,等.冠心病经皮冠状动脉介入治疗术后患者出院准备度现状及影响因素分析[J].中国实用护理杂志,2020,36(20):1547~1553. [6] 王艳霞,徐凯,李田昌,等.接受急诊经皮冠状动脉介入治疗青年患者临床特征及疗效分析[J].临床军医杂志,2020,48(5):82~84,87. [7] 董南.经皮冠状动脉介入术联合主动脉内球囊反搏对ST段抬高型心肌梗死患者术后高血栓负荷的影响[J].血栓与止血学,2019,25(2):239~241. [8] 董艳丽,董淑娟.替格瑞洛片联合阿司匹林片用于经皮冠状动脉介入术的急性ST段抬高型心肌梗死患者的临床研究[J].中国临床药理学杂志,2019,35(7):614~616. [9] Chen S,Kawasaki Y,Hu H,et al.Smoking cessation,weight Gain,and the trajectory of estimated risk of coronary heart disease:8-year follow-up from a prospective cohortStudy[J].Nicotine & tobacco research:official journal of the Society for Research on Nicotineand Tobacco,2021,23(1):85~91. [10] 魏稳稳,任伯绪,邓文芳,等.冠心病患者PCI术后生活质量的影响因素及干预措施[J].长江大学学报(自科版),2019,16(12):102~106.
2022, Vol. 28 
冀公网安备13080202000677号