Abstract：Objective: To investigate the difference between two proteins in cell proliferation and differentiation by analyzing the expression of Keratin CK10 and CK19 in SK and BCC. And to analyze the diagnosis, treatment and prognosis of the two diseases according to the different expression of CK10 and CK19 in different tissues. Methods: The expression of CK10 and CK19 in 40 cases of SK and 40 cases of BCC were observed by immunohistochemistry, and analyzed statistically. Results: The expression of CK10 in SK was significantly higher than that in BCC (P<0.01).The expression of CK19 in BCC was significantly higher than that in SK (P<0.01) . Conclusion: The study further demonstrated that the SK was well differentiated and benign; the basal-cell Carcinoma cells remain undifferentiated and malignant; there are obvious differences.
孙业晓, 申志华, 张艳峰, 缪希红, 段庆华. CK10和CK19在脂溢性角化病和基底细胞癌中的表达和作用[J]. 河北医学, 2022, 28(2): 305-307.
SUN Yexiao, SHEN Zhihua, ZHANG Yanfeng, et al. Expression and Role of CK10 and CK19 in SK and BCC. HeBei Med, 2022, 28(2): 305-307.
[1] Del Rosso JQ.A closer look at seborrheic keratoses:patient perspectives,clinical relevance,medical necessity,and implication for management[J].Clin Aesthet Dermatol,2017,10(3):16~25. [2] Gutzmer R,Solomon JA.Hedgehog pathway inhibition for the treatment of basal cell carcinoma[J].Target Oncol,2019,14(3):253~267 [3] Fernandez-Flores A.Skin Biopsy in the Context of systemic disease[J].Actas Dermosifiliogr,2019,110(9):710~727 [4] Li HY Cui DX,Wu S et al.Epigenetic regulation of gene expression in epithelial stem cells fate[J] Current stem cell research therapy,2018,13(1):46~51 [5] Karantza V.Keratins in health and cancer:more than mere epithelial cell markers[J].Oncogene,2011,30(2):127~138 [6] Aslan F,Demirkesen C,Cagatay P,et al.Expression of cytokeratin subtypes in intraepidermal malignancies:a guide for differentiation [J].Cutan Pathol,2006,33(8):531~538. [7] Liu QW,He XJ,Zhang JC,et al.Research progress of wound repair on skin tissue with stem cells[J].Chinese Journal of Aesthetic Medicin,2019,28(6):159~164. [8] Yay A,Guktepe O,Behadira,et al.Assessment of markers expressed in human hair follicles according to different skin regions[J].Adv Clin Exp Med,2018,27(7):929~939.
2022, Vol. 28 
冀公网安备13080202000677号