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河北医学  2022, Vol. 28 Issue (2): 301-305    DOI: 10.3969/j.issn.1006-6233.2022.02.025
  临床研究 本期目录 | 过刊浏览 | 高级检索 |
血清CXCL-10和IL-27水平与艰难梭菌感染腹泻患者病情程度的相关性分析
张金仿1, 张宇蔺2
1.首都医科大学附属北京友谊医院, 北京 100050
2.南京医科大学附属苏州医院医学检验科, 江苏 苏州 215002
Correlation Between Serum CXCL-10 and IL-27 Levels and Severity of Diarrhea Patients with Clostridium Difficile Infection
ZHANG Jinfang, et al
Beijing Friendship Hospital,Capital Medical University, Beijing 100050,China
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摘要 目的: 研究艰难梭菌感染(CDI)腹泻患者血清CXC趋化因子配体-10(CXCL-10)和白介素-27(IL-27)水平的变化及其与病情严重程度间的相关性。方法: 将150例腹泻患者根据Cd培养结果是否阳性将其观察组(Cd培养阳性者,n=90)和对照组(Cd培养阴性者,n=60),观察组患者又根据CDI疾病严重程度(severity score index,SSI)评分将其分为轻度亚组(评分<4分,n=38)和中—重度亚组(评分≥4分,n=52)。所有人员进行血清CXCL-10和IL-27检测,比较三组人员血清CXCL-10和IL-27水平间的差异,并分析血清CXCL-10和IL-27与CDI腹泻严重程度间的相关性。结果: 三组人员血清CXCL-10和IL-27水平高低为:观察组>对照组>健康组(P<0.05);观察组中—重度亚组患者血清CXCL-10和IL-27水平明显高于轻度亚组(P<0.05)。观察组SSI评分为(4.68±1.73)分,其中轻度亚组SSI评分为(3.02±0.89)分,中—重度亚组SSI评分为(5.13±1.09)分。Spearman直线相关性分析发现观察组患者血清CXCL-10和IL-27水平与SSI评分间呈正相关性(r=0.317和0.368,P=0.002和0.000)。ROC曲线分析发现:血清CXCL-10、IL-27及二者联合对CDI腹泻的诊断曲线下面积(area under curve,AUC)分别为:0.846、0.853和0.874,诊断敏感性分别为85.25%、80.30%和82.75%,诊断特异性分别78.50%、82.55%和85.85%。结论: 血清CXCL-10和IL-27有助于艰难梭菌感染腹泻患者病情严重程度的判断,具临床应用价值。
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张金仿
张宇蔺
关键词 艰难梭菌CXC趋化因子配体-10白介素-27腹泻    
AbstractObjective: To study the changes of serum CXCL chemokine ligand-10 (CXCL-10) and interleukin-27 (IL-27) levels in diarrhea patients with Clostridium difficile infection (CDI) and their correlation with the severity of the disease. Metods: A total of 150 patients with diarrhea were divided into observation group (positive Cd culture,n=90) and control group (negative Cd culture,n=60) according to the results of Cd culture. The patients in observation group were further divided into mild subgroup (score<4,n=38) and moderate-severe subgroup (score≥4,n=52) according to the severity score (SSI) of CDI. The serum levels of CXCL-10 and IL-27 were detected in all the three groups, and the correlation between the serum levels of CXCL-10 and IL-27 and the severity of CDI diarrhea was analyzed. Results: The serum levels of CXCL-10 and IL-27 in the three groups were as follows: observation group>control group>healthy group (P<0.05);the serum levels of CXCL-10 and IL-27 in the moderate-severe subgroup were significantly higher than those in the mild subgroup (P<0.05).The SSI score of the observation group was (4.68±1.73), the SSI score of the mild subgroup was (3.02±0.89), and the SSI score of the moderate-severe subgroup was (5.13±1.09). Spearman linear correlation analysis showed that there was a positive correlation between serum CXCL-10 and IL-27 levels and SSI score in the observation group (r=0.317 and 0.368,P=0.002 and 0.000). ROC curve analysis showed that the area under curve (AUC) of serum CXCL-10, IL-27 and their combination in the diagnosis of CDI diarrhea were 0.846, 0.853 and 0.874 respectively, the diagnostic sensitivity was 85.25%, 80.30% and 82.75% respectively, and the diagnostic specificity was 78.50%, 82.55% and 85.85% respectively. Conclusion: Serum CXCL-10 and IL-27 can help judge the severity of diarrhea in patients with Clostridium difficile infection, which has clinical application value.
Key wordsClostridium difficile    CXCL-10    IL-27    Diarrhea
    
基金资助:国家自然科学基金,(编号:81802064);首都医科大学附属北京友谊医院“种子计划”人才项目,(编号:YYZZ2018B01)
通讯作者: 张宇蔺   
引用本文:   
张金仿, 张宇蔺. 血清CXCL-10和IL-27水平与艰难梭菌感染腹泻患者病情程度的相关性分析[J]. 河北医学, 2022, 28(2): 301-305.
ZHANG Jinfang, et al. Correlation Between Serum CXCL-10 and IL-27 Levels and Severity of Diarrhea Patients with Clostridium Difficile Infection. HeBei Med, 2022, 28(2): 301-305.
链接本文:  
http://www.hbyxzzs.cn/CN/10.3969/j.issn.1006-6233.2022.02.025     或     http://www.hbyxzzs.cn/CN/Y2022/V28/I2/301
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