超声引导下腰骶神经丛阻滞联合吸入麻醉对全髋关节置换术患者氧化应激 免疫功能及认知功能的影响

doi:10.3969/j.issn.1006-6233.2022.02.020

摘要
图/表
参考文献
相关文章 (15)

全文: PDF (1229 KB) HTML (1 KB)
输出: BibTeX | EndNote (RIS)

摘要 目的: 探究超声引导下腰骶神经丛阻滞联合吸入麻醉对全髋关节置换术患者氧化应激、免疫功能及认知功能的影响。方法: 选取2018年12月至2020年12月本院收治的行全髋关节置换术患者120例。按照随机数字表简单随机分为对照组与研究组,各60例。对照组患者采取吸入麻醉,研究组患者采用超声引导下腰骶神经丛阻滞联合吸入麻醉,比较两组患者术前、术后1d、术后3d、氧化应激、免疫功能及认知功能指标差异。结果: 术前,两组SOD、MDA、CD3⁺、CD4⁺、CD8⁺、NK水平、MMSE分值比较差异无统计学意义(P>0.05);术后1d、术后3d,研究组SOD、CD3⁺、CD4⁺、NK水平、MMSE分值均高于对照组,MDA、CD8⁺水平均低于对照组,差异有统计学意义(P<0.05)。结论: 超声引导下腰骶神经丛阻滞联合吸入麻醉应用于全髋关节置换术患者可有效降低氧化应激反映,缓解免疫功能抑制,减少认知功能损伤,值得临床推广应用。

	服务

	把本文推荐给朋友
	加入我的书架
	加入引用管理器
	E-mail Alert
	RSS
	作者相关文章
	董碧倩
	范婉秋
	高勤

关键词 ：全髋关节置换术, 超声引导下腰骶神经丛阻滞, 吸入麻醉, 氧化应激, 免疫功能, 认知功能

Abstract：Objective: To investigate the effects of ultrasound-guided lumbosacral plexus block combined with inhalation anesthesia on oxidative stress, immune function and cognitive function in patients with total hip arthroplasty. Methods: 120 patients undergoing total hip arthroplasty in our hospital from December 2018 to December 2020 were selected. According to the random number table, they were divided into control group and study group, 60 cases in each. The patients in the control group were treated with inhalation anesthesia, and the patients in the study group were treated with ultrasound-guided lumbosacral plexus block combined with inhalation anesthesia, to compare the data of oxidative stress, immune function and cognitive function between the two groups before operation and 1d, 3d after operation. Results: There was no significant difference in SOD,MDA,CD3⁺,CD4⁺,CD8⁺,NK level and MMSE score between the two groups before operation (P>0.05). The SOD,CD3⁺,CD4⁺,NK level and MMSE score of the study group 1 d after operation were higher than those of the control group, and the MDA, CD8⁺ level were lower than those of the control group (P>0.05). Conclusion: Ultrasonic guided lumbosacral plexus block combined with inhalation anesthesia in patients with total hip arthroplasty can effectively reduce oxidative stress response, alleviate immunosuppression and reduce cognitive impairment, which is worthy of clinical application.

Key words： Total hip replacement Ultrasound-guided lumbosacral plexus block Inhalation anesthesia Oxidative stress Immune function Cognitive function

基金资助:四川省卫生和计划生育委员会课题项目,(编号:17PJ131)

通讯作者: 高勤

引用本文:

董碧倩, 范婉秋, 高勤. 超声引导下腰骶神经丛阻滞联合吸入麻醉对全髋关节置换术患者氧化应激免疫功能及认知功能的影响[J]. 河北医学, 2022, 28(2): 277-281.
DONG Biqian, FAN Wanqiu, GAO Qin. Effects of Ultrasound-Guided Lumbosacral Plexus Block Combined with Inhalation Anesthesia on Oxidative Stress, Immune Function and Cognitive Function in Patients Undergoing Total Hip Arthroplasty. HeBei Med, 2022, 28(2): 277-281.

链接本文:

http://www.hbyxzzs.cn/CN/10.3969/j.issn.1006-6233.2022.02.020 或 http://www.hbyxzzs.cn/CN/Y2022/V28/I2/277

[1] 史雅娟.联合神经阻滞麻醉对全髋关节置换术老年患者术后镇痛效果和免疫功能的影响[J].河北医学,2019,25(8):1344~1347.
[2] Perioperative anaesthesia and coagulation management of haemophilia patients receiving total hip and knee replacement arthroplasty:experience from a case series[J].Journal of Orthopaedic Surgery,2019,27(3):23.
[3] 席拴才.超声引导下腰骶神经丛阻滞联合吸入麻醉对老年髋关节置换术患者氧化应激水平和认知功能的影响[J].中国药物与临床,2019,19(9):106~108.
[4] Xin Ying,Chua,Robin Wai Munn,et al.Mapping modified mini-mental state examination (MMSE) scores to dementia stages in a multi-ethnic asian population.[J].International psychogeriatrics,2019,31(1):147~151.
[5] 董大龙,张明明,王安奎,等.超声引导下腰骶丛神经阻滞联合喉罩浅全麻在老年患者全髋关节置换术中的应用[J].实用临床医药杂志,2019,23(2):70~73,77.
[6] 汤裕泉,王胜斌.超声下腰骶丛神经阻滞对老年髋关节置换术患者术后康复的影响[J].中国数字医学,2019,14(6):70~72.
[7] 何金乾.超声引导下腰骶神经丛阻滞联合吸入麻醉在老年全髋关节置换术中的应用[J].新乡医学院学报,2018,35(9):799~803.
[8] 刘艳,夏洁,彭宗军,等.丙泊酚麻醉对颅脑外伤患者氧化应激,神经功能及炎症因子水平的影响[J].海南医学院学报,2017,24(23):146~149.
[9] 董建军,姚型柱,吴超贤.B超引导下骶丛神经阻滞对髋关节置换术患者应激及免疫功能的影响[J].重庆医学,2019,48(12):2061~2066.
[10] 史雅娟.联合神经阻滞麻醉对全髋关节置换术老年患者术后镇痛效果和免疫功能的影响[J].河北医学,2019,25(8):1344~1347.
[11] 陈元良,徐丽丽,蓝志坚,等.七氟烷与丙泊酚联合右美托咪定对行腹腔镜胆囊切除术患者术后认知功能及氧化应激反应的影响[J].中华全科医学,2017,15(8):1283~1285.