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河北医学  2022, Vol. 28 Issue (12): 2086-2089    DOI: 10.3969/j.issn.1006-6233.2022.12.029
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心电图最深S波QT间期离散度与原发性高血压合并左心室肥厚患者血压变异性NT-proBNP的相关性分析
王妍嫣, 迪丽努尔·买买提江, 努尔比亚·艾合买提, 祖鲁胡玛尔·肉苏力, 佘强国, 买力旦木·艾克拜
新疆医科大学第二附属医院心电图室, 新疆 乌鲁木齐 830068
Correlation of the Deepest S Wave and QT Interval Dispersion of the Electrocardiogram with Blood Pressure Variability and NT-proBNP in Patients with Essential Hypertension Combined with Left Ventricular Hypertrophy
WANG Yanyan, Dili Nur Maimaitijiang, Nurbiya Aihemaiti, et al
The Second Affiliated Hospital of Xinjiang Medical University, Xinjiang Urumqi 830068, China
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摘要 目的: 分析心电图最深S波(SD)、QT间期离散度(QTcd)与原发性高血压合并左心室肥厚(LVH)患者血压变异性、氨基末端脑钠肽前体(NT-proBNP)的相关性。方法: 选择2021年1月至2022年6月医院收治的原发性高血压患者304例为研究对象,据其是否合并LVH分为LVH组(n=173)和非LVH组(n=131)。比较两组SD、QTcd、血压变异性以及血清NT-proBNP水平,采用Pearson相关分析SD、QTcd与原发性高血压合并LVH患者血压变异性、NT-proBNP的相关性。结果: LVH组SD、QTcd明显高于非LVH组(P<0.05);LVH组24h SCV、24h DCV、dSCV、dDCV、nSCV和nDCV均明显高于非LVH组(P<0.05);LVH组血清NT-proBNP水平明显高于非LVH组(P<0.05);SD、QTcd与原发性高血压合并LVH患者24h SCV、24h DCV、dSCV、dDCV、nSCV、nDCV均呈明显正相关(P<0.05);SD、QTcd与原发性高血压合并LVH患者NT-proBNP均呈明显正相关(P<0.05)。结论: 原发性高血压合并LVH患者SD、QTcd明显升高,可能与患者血压变异性及血清NT-proBNP水平有关。
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关键词 原发性高血压左心室肥厚心电图最深S波QT间期离散度血压变异性氨基末端脑钠肽前体    
AbstractObjective: To analyze the correlation of the deepest S wave (SD) and QT (QTcd) interval dispersion of the electrocardiogram with blood pressure variability and NT-proBNP in patients with essential hypertension combined with left ventricular hypertrophy (LVH). Methods: A total of 304 patients with essential hypertension who were treated in the hospital from January 2021 to June 2022 were selected as the research subjects. According to whether the patients were accompanied by LVH or not, they were divided into LVH group (n=173) and non-LVH group (n=131). The SD, QTcd, blood pressure variability and serum NT-proBNP level were compared between the two groups, and the correlation between SD, QTcd and blood pressure variability and NT-proBNP in patients with essential hypertension and LVH was analyzed using Pearson correlation analysis. Results: SD and QTcd in LVH group were significantly higher than those in non-LVH group (P<0. 05). The 24h SCV, 24h DCV, dSCV, dDCV, nSCV and nDCV were significantly higher in LVH group than those in non-LVH group (P<0. 05). Serum NT-proBNP level in LVH group was significantly higher compared to non-LVH group (P<0. 05). SD and QTcd were significantly positively correlated with 24h SCV, 24h DCV, dSCV, dDCV, nSCV and nDCV in patients with essential hypertension and LVH (P<0. 05). SD and QTcd were significantly positively correlated with NT-proBNP in patients with essential hypertension complicated with LVH (P<0. 05). Conclusion: SD and QTcd in patients with essential hypertension complicated with LVH are significantly increased, which may be related to blood pressure variability and serum NT-proBNP level.
Key wordsEssential hypertension    Left ventricular hypertrophy    Electrocardiogram deepest S wave    QT interval dispersion    Blood pressure variability    N-terminal pro-B-type natriuretic peptide
    
基金资助:省部共建中亚高发病成因与防治国家重点实验室开放课题项目,(编号:SKL-HIDCA-2020-EF3)
通讯作者: 买力旦木·艾克拜   
引用本文:   
王妍嫣, 迪丽努尔·买买提江, 努尔比亚·艾合买提, 祖鲁胡玛尔·肉苏力, 佘强国, 买力旦木·艾克拜. 心电图最深S波QT间期离散度与原发性高血压合并左心室肥厚患者血压变异性NT-proBNP的相关性分析[J]. 河北医学, 2022, 28(12): 2086-2089.
WANG Yanyan, Dili Nur Maimaitijiang, Nurbiya Aihemaiti, et al. Correlation of the Deepest S Wave and QT Interval Dispersion of the Electrocardiogram with Blood Pressure Variability and NT-proBNP in Patients with Essential Hypertension Combined with Left Ventricular Hypertrophy. HeBei Med, 2022, 28(12): 2086-2089.
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