外阴硬化性苔藓聚焦超声治疗的临床效果分析

doi:10.3969/j.issn.1006-6233.2022.12.020

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摘要 目的: 通过观察聚焦超声对外阴硬化性苔藓患者治疗前后的症状和体征,探讨聚焦超声的临床治疗效果。方法: 选择2019年7月至2020年6月接诊并实施治疗的外阴硬化性苔藓患者76例,随机分为研究组和对照组,各38例。对照组接受丙酸睾酮注射液治疗,研究组接受聚焦超声治疗(每隔7~10d治疗1次,连续治疗6次)。对比两组患者的疗效、瘙痒程度、复发率,选择SF-36生活质量调查问卷表评估两组患者健康状况。结果: 与对照组比较,研究组的治疗总有效率显著升高,有统计学意义(97.37%vs78.95% χ²=6.176 P=0.013);复发率减低,有统计学意义(2.63%vs18.42% χ²=5.029 P=0.025);与对照组比较,治疗前研究组的瘙痒程度评分、SF-36评分与之无统计学意义(2.72±0.25分vs2.70±0.24分t=0.356 P=0.723,650.33±26.71分vs651.71±27.42分t=0.222 P=0.825);治疗1个月、3个月、6个月研究组的瘙痒程度评分均减低,有统计学意义(2.26±0.26分vs2.51±0.25分t=4.273 P=0.001,1.69±0.28分vs2.18±0.35分t=6.739 P=0.001,1.07±0.31分vs1.82±0.35分t=9.888 P=0.001),治疗1个月、3个月、6个月研究组的SF-36评分均升高,有统计学意义(675.62±24.46分vs662.51±25.22分t=2.300 P=0.024,692.65±22.68分vs678.41±22.53分t=2.746 P=0.008,727.91±21.52与vs701.45±20.49分t=5.489 P=0.001)。结论: 对外阴硬化性苔藓患者实施聚焦超声治疗,对其瘙痒症状的缓解效果明显,并且治疗后的复发率低,有利于促进患者生活质量提升。

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关键词 ：聚焦超声, 外阴硬化性苔藓, 瘙痒程度, 复发, 生活质量

Abstract：Objective: To analyze the clinical effect of focused ultrasound in patients with vulvar sclerosing moss. Methods: 76 patients with vulvar sclerosing moss who were admitted and treated from July 2019 to June 2020 were randomly divided into the study group and the control group, 38 patients in each group. The control group received testosterone propionate injection, and the study group received focused ultrasound treatment (once every 7-10 days, 6 consecutive times). The efficacy, pruritus degree and recurrence rate of the two groups were compared, and the SF-36 quality of life questionnaire was selected to evaluate the health status of the two groups. Results: Comparing the two groups, the total effective rate of treatment in the research group is higher, with statistical significance (97. 37% vs 78. 95% χ²=6. 176 P=0. 013); the recurrence rate was decreased, with statistical significance (2. 63% vs 18. 42%) χ²=5. 029 P=0. 025). The itching degree score and SF-36 score of the research group before treatment had no statistical significance (2. 72±0. 25 points vs 2. 70±0. 24 points t=0. 356 P=0. 723, 650. 33±26. 71 points vs 651. 71± 27. 42 points t=0. 222 P=0. 825); the pruritus degree scores of the research group after 1 month, 3 months and 6 months of treatment were all decreased, with statistical significance (2. 26±0. 26 points vs 2. 51±0. 25 points t=4. 273 P =0. 001, 1. 69±0. 28 points vs 2. 18±0. 35 points t=6. 739 P=0. 001, 1. 07±0. 31 points vs 1. 82±0. 35 points t=9. 888 P=0. 001), 1 month, 3 months, 6 months of treatment The SF-36 scores of the research group were all increased, with statistical significance (675. 62±24. 46 points vs 662. 51±25. 22 points t=2. 300 P=0. 024, 692. 65±22. 68 points vs 678. 41±22. 53 points t=2. 746 P=0. 008, 727. 91±21. 52 vs 701. 45±20. 49 points t=5. 489 P=0. 001). Conclusion: Focused ultrasound therapy for patients with vulvar sclerosing moss can significantly relieve itching symptoms, and the recurrence rate after treatment is low, which is conducive to improving the quality of life of patients.

Key words： Focused ultrasound Vulvar sclerosing moss Itching degree Recurrence Quality of life

基金资助:河北省承德市科学技术研究计划与发展项目,(编号:202109A010)

通讯作者: 栾燕东

引用本文:

王晓伟, 栾燕东, 刘军, 董志伟, 孙淑红. 外阴硬化性苔藓聚焦超声治疗的临床效果分析[J]. 河北医学, 2022, 28(12): 2044-2046.
WANG Xiaowei, et al. Clinical Effect of Focused Ultrasound in the Treatment of vulvar sclerosing moss. HeBei Med, 2022, 28(12): 2044-2046.

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http://www.hbyxzzs.cn/CN/10.3969/j.issn.1006-6233.2022.12.020 或 http://www.hbyxzzs.cn/CN/Y2022/V28/I12/2044