慢性阻塞性肺病患者急性加重期低氧血症血清肌钙蛋白及心肌酶水平变化及临床意义的探讨

doi:10.3969/j.issn.1006-6233.2022.12.017

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摘要 目的: 探讨慢性阻塞性肺病(COPD)患者急性加重期伴低氧血症患者血清肌钙蛋白、心肌酶水平变化及其临床意义。方法: 选取2020年1月至2022年1月本院收集的慢性阻塞性肺病急性加重期(AECOPD)患者123例,将动脉氧分压(PaO₂)值≥60mmHg患者62例纳入对照组(n=62),PaO₂值<60mmHg的61例AECOPD患者纳入观察组(n=61);比较两组血清肌钙蛋白I(cTnI)、肌酸激酶(CK)和肌酸激酶同工酶(CK-MB)水平,不同低氧血症严重程度的AECOPD患者血清cTnI、CK、CK-MB,Spearman相关性分析法分析低氧血症严重程度与血清cTnI、CK、CK-MB的关系。结果: 观察组血清cTnI、CK、CK-MB水平高于对照组(P<0.05);不同低氧血症严重程度的AECOPD患者血清cTnI、CK、CK-MB比较差异有统计学意义(P<0.05);其中中度、重度低氧血症患者cTnI、CK、CK-MB高于轻度组,重度低氧血症患者cTnI、CK、CK-MB高于中度组(P<0.05);Spearman相关性分析显示,低氧血症严重程度与血清CTnI、CK、CK-MB呈正相关关系(r=0.916、0.665、0.805,均P<0.05)。结论: AECOPD伴低氧血症患者血清cTnI、CK、CK-MB水平高于单纯AECOPD患者,且血清cTnI、CK、CK-MB水平与低氧血症严重程度正相关,值得临床重视。

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	王熹
	董琳
	杨万春

关键词 ：慢性阻塞性肺病, 低氧血症, 肌钙蛋白I, 肌酸激酶, 肌酸激酶同工酶

Abstract：Objective: To investigate the changes and clinical significance of serum troponin and myocardial enzymes in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) and hypoxemia. Methods: A total of 123 patients with AECOPD admitted to the hospital from January 2020 to January 2022 were selected. Patients with arterial partial pressure of oxygen (PaO₂) ≥ 60 mmHg were included in the control group (n=62), and patients with PaO₂ <60 mmHg were included in the observation group (n=61). The levels of serum troponin I (cTnI), creatine kinase (CK) and creatine kinase isoenzyme (CK-MB) were compared between the groups, and between patients with different severity of hypoxemia. Spearman correlation analysis was performed to analyze the relationship between the severity of hypoxemia and serum cTnI, CK and CK-MB. Results: The levels of serum cTnI, CK and CK-MB in the observation group were significantly higher than those in the control group (P<0. 05). The levels of serum cTnI, CK and CK-MB increased with the aggravation of hypoxemia (P<0. 05). Spearman correlation analysis showed that the severity of hypoxemia was significantly positively correlated with serum CTnI, CK and CK-MB (r=0. 916, 0. 665, 0. 805, P<0. 05). Conclusion: The levels of serum cTnI, CK and CK-MB in patients with AECOPD and hypoxemia are higher than those in patients with simple AECOPD. The levels of serum cTnI, CK and CK-MB are positively correlated with the severity of hypoxemia, which deserves clinical attention.

Key words： Chronic obstructive pulmonary disease Hypoxemia Troponin I Creatine kinase Creatine kinase isoenzyme

基金资助:2018年度安徽省学术和技术带头人及后备人选科研活动经费资助项目,(编号:2018H193)

通讯作者: 杨万春

引用本文:

王熹, 董琳, 杨万春. 慢性阻塞性肺病患者急性加重期低氧血症血清肌钙蛋白及心肌酶水平变化及临床意义的探讨[J]. 河北医学, 2022, 28(12): 2031-2033.
WANG Xi, DONG Lin, YANG Wanchun. Changes and Clinical Significance of Serum Troponin and Myocardial Enzymes in Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease and Hypoxemia. HeBei Med, 2022, 28(12): 2031-2033.

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http://www.hbyxzzs.cn/CN/10.3969/j.issn.1006-6233.2022.12.017 或 http://www.hbyxzzs.cn/CN/Y2022/V28/I12/2031

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