Expression and Clinical Significance of Serum IGF-1 IL-6 and IL-10 in Patients with Acute Respiratory Distress Syndrome after Valve Replacement under Extracorporeal Circulation
CHEN Yongliang, et al
The Affiliated Hospital of Chengde Medical University, Hebei Chengde 067000, China
Abstract：Objective: To investigate the levels of serum IGF-1, IL-6, IL-10 in patients with acute respiratory distress syndrome after valve replacement under extracorporeal circulation and their correlation with prognosis. Methods: 211 patients who underwent valve replacement under extracorporeal circulation in our hospital from December 2016 to December 2020 were divided into ARDA group and non-ARDS group according to whether they developed acute respiratory distress syndrome after operation. Arterial blood gas analysis was collected after anesthesia induction and before extracorporeal circulation, 2h, 6h, 12h and 24h after extracorporeal circulation (recorded as T1~T5), and oxygenation index (OI) was calculated; the venous blood of patients was collected at T1-T5. The levels of IGF-1, IL-6 and IL-10 in serum were measured by ELISA. The change trends of IGF-1, IL-6 and IL-10 in serum and their effects on postoperative acute respiratory distress syndrome were analyzed. Results: The serum concentrations of IGF-1, IL-6 and IL-10 in patients with ARDS after valve replacement under extracorporeal circulation were significantly higher than those before operation, and showed an upward trend within 24 hours after operation; the serum concentrations of IGF-1, IL-6 and IL-10 in ARDS group were significantly higher than those in non ARDS group at 12 and 24 hours after operation (P<0. 05). In ARDS group, the concentration of cytokines at 24h after valve replacement under CPB and OI at 24h after operation were analyzed by Pearson correlation. The results showed that the concentration of IGF-1 at 24h after CPB was correlated with OI at 24h after operation (r=0. 808, P<0. 001); IL-6 at 24h after CPB was correlated with OI at 24h after CPB (r=0. 737, P=0. 001). Conclusion: The serum concentrations of IGF-1, IL-6 and IL-10 in patients with acute respiratory distress syndrome after valve replacement under extracorporeal circulation are significantly higher than those without extracorporeal circulation. The serum concentrations of IGF-1, IL-6 and IL-10 are closely related to the occurrence and development of acute respiratory distress syndrome after valve replacement under extracorporeal circulation, which has certain guiding significance for predicting the complication of acute respiratory distress syndrome after valve replacement under extracorporeal circulation.
2022, Vol. 28 
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