Abstract：Objective: To analyze the correlation of serum chemokine, RNAKL and 25- hydroxy vitamin D [25(OH)D] levels with disease progression in rheumatoid arthritis.Methods: 289 patients with rheumatoid arthritis diagnosed and treated in our hospital from January 2019 to December 2021, and 100 healthy subjects who underwent physical examination in our hospital simultaneously, were included for the study. RA patients were divided into RA remission group and RA activity group using disease activity score 28-jointcount. Fasting serum levels of C-C chemokine ligand 20 (CCL20), RNAKL and 25(OH)D were determined in RA patients and healthy subjects.And DAS28 score was used as a variable of RA disease progression to analyze the correlation between the above indicators and RA disease progression. Results: Compared with the control group, the serum levels of CCL20 and RNAKL in RA patients were significantly increased, while the level of 25(OH)D was significantly decreased, the difference was statistically significant(P<0.05). Serum levels of CCL20 and RNAKL in RA activity group were significantly higher than those in RA remission group, the difference was statistically significant(P<0.05). Serum 25(OH)D levels in RA activity group were significantly lower than those in RA remission group, the difference was statistically significant(P<0.05). Using DAS28 score as a variable for RA disease progression, correlation analysis showed that serum CCL20 and RNAKL levels were positively correlated with the DAS28 score (P<0.05), while serum 25(OH)D levels were negatively correlated with the DAS28 score (P<0.05). Conclusion: Serum levels of CCL20, RNAKL and 25(OH)D are correlated with the progression of RA, and CCL20, RNAKL and 25(OH)D can be used as biological indicators to monitor disease activity and assist doctors to judge patients' conditions comprehensively.
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2022, Vol. 28 
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