Study on the Effects of Different Doses of Levothyroxine Dodium Tablet Treatment on Thyroid Hormones,Pregnancy Outcome and Offspring Psychological Developmental Functions in Pregnant Women with Hypothyroidism During Pregnancy
SHI Youwen, GAN Yu, XIE Qianqian, et al
No.901 Hospital,Joint Logistics Support Force of the Chinese People's Liberation Army, Anhui Hefei 230031, China
Abstract：Objective: To study the effects of different doses of levothyroxine sodium tablets on thyroid hormones,pregnancy outcomes and offspring psychological development of women with hypothyroidism during pregnancy. Methods: A total of 100 pregnant women with hypothyroidism treated with levothyroxine sodium tablets in the hospital from August 2020 to August 2021 were selected.They were divided into group A (25ug/time,54 cases),group B (50ug/time,25 cases) and group C (75ug/time,21 cases) according to the dose.Relevant parameters in the three groups were comparatively analyzed. Results: Thyroid function indicators in the three groups showed no statistically significant difference before treatment (P>0.05).After treatment,the levels of thyroid stimulating hormone (TSH) and thyroid peroxidase antibody (TPO-Ab) were significantly decreased,and the levels of free triiodothyronine (FT3) and free thyroxine (FT4) were significantly increased in all groups.The increases or decreases were significantly greater in group C than in group A and group B (P<0.05).The glucose and lipid metabolism in the three groups showed no statistically significant difference before treatment (P>0.05).After treatment,fasting plasma glucose (FPG),fasting insulin (FINS),total cholesterol (TC),low-density lipoprotein cholesterol (HDL-C),and triglyceride (TG) were decreased,while high-density lipoprotein Cholesterol (HDL-C) was increased in the three groups.The changes in group C were greater than those in group A and group B (P<0.05).There were significant differences in the incidence rates of gestational diabetes mellitus and premature rupture of membranes among the 3 groups (P<0.05).The incidence of gestational diabetes mellitus in group C was significantly lower than that in group A (P<0.05).The other pregnancy outcomes of the 3 groups showed no statistically significant difference (P>0.05).The scores of offspring's gross motor,adaptability and social behavior in group C were significantly higher than those in group A and group B (P<0.05),but there was no statistically significant difference in language and fine motor (P>0.05). Conclusion: Compared with low-dose levothyroxine sodium tablets,high-dose levothyroxine sodium tablets can better maintain normal thyroid function in pregnant women with hypothyroidism,regulate their glucose and lipid metabolism,lower the risk of adverse pregnancy outcomes,and improve offspring's neuropsychological development.
施友文, 甘雨, 谢倩倩, 邓竹琴, 俞敏. 不同剂量左甲状腺素钠片治疗对妊娠期甲状腺功能减退症孕妇甲状腺激素妊娠结局及子代心理发育功能的影响研究[J]. 河北医学, 2022, 28(10): 1748-1753.
SHI Youwen, GAN Yu, XIE Qianqian, et al. Study on the Effects of Different Doses of Levothyroxine Dodium Tablet Treatment on Thyroid Hormones,Pregnancy Outcome and Offspring Psychological Developmental Functions in Pregnant Women with Hypothyroidism During Pregnancy. HeBei Med, 2022, 28(10): 1748-1753.
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2022, Vol. 28 
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