乳腺癌磁共振参数与表皮生长因子受体2 增殖细胞核抗原相关性

doi:10.3969/j.issn.1006-6233.2022.10.020

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摘要 目的: 探究磁共振(MRI)T2WI信号特征、表观弥散系数(ADC)值对乳腺癌患者人类表皮生长因子受体2(cerbB-2)及,增殖细胞核抗原(Ki-67)表达的相关性。方法: 选取我院2017年6月至2021年4月收治乳腺癌患者117例,所有患者均行常规MRI影像检查、标本免疫组织化学染色检测,记录MRI影像检查所得T2WI信号特征、ADC值与免疫组织化学检测cerbB-2、Ki-67阳性情况,分析其相关性。结果: 结果显示cerbB-2表达阳性、阴性时ADC值分别为(0.81±0.11)、(0.90±0.15),cerbB-2阳性表达T2WI多为高信号,ADC值明显升高(P<0.05)。Ki-67表达阳性、阴性时T2WI信号及ADC值存在明显差异,阳性表达T2WI多为高信号,ADC值明显降低(P<0.05)。T2WI高信号、ADC值升高为cerbB-2阳性影响因素,且两者与其呈正相关性(r=0.372、r=0.310,P<0.001、P=0.001);T2WI高信号、ADC值降低为Ki-67阳性影响因素,T2WI信号与Ki-67正相关,ADC值与其呈负相关(r=0.274、r=-0.476,P=0.003、P<0.001)。结论: 本文抛开乳腺癌临床常用超声及钼靶X线检查手段,以MRI检查为主要突破点,探讨T2WI信号、ADC值与机体生物因子相关系。多数研究分析MRI检查结果以ADC值与为重点,忽视T2WI信号在评估乳腺癌与机体生物因子间作用。本文通过将ADC值、T2WI信号与生物因子结合,为寻找乳腺癌治疗新靶点提供支撑。乳腺癌患者MRI检查多伴有高T2WI信号、ADC值降低特征。T2WI信号、ADC值与患者cerbB-2及Ki-67表达存在一定联系,cerbB-2及Ki-67可为后续乳腺癌治疗提供参考价值。

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	吴丽萍
	张南
	刘文霞

关键词 ：乳腺癌, 磁共振, 人类表皮生长因子受体2, 增殖细胞核抗原

Abstract：Objective: To explore the correlation between T2WI signal characteristics and apparent diffusion coefficient (ADC) of MRI and cerbB-2 and Ki-67 expression in breast cancer patients. Methods: One hundred and seventeen breast cancer patients admitted to our hospital from June 2017 to April 2021 were selected.All patients underwent routine MRI imaging and immunohistochemical staining of specimens,and the correlation between T2WI signal characteristics and ADC values obtained from MRI imaging and immunohistochemical detection of cerbB-2 and Ki-67 positivity was recorded and analyzed. Results: The ADC values were (0.81±0.11) and (0.90±0.15) for positive and negative expression of cerbB-2,respectively,and the T2WI signal and ADC values were significantly higher for positive expression of cerbB-2 (P<0.05).T2WI high signal and ADC values were significantly lower (P<0.05).T2WI high signal and ADC values were factors influencing cerbB-2 positivity,and both were positively correlated with it (r=0.372,r=0.310,P<0.001,P=0.001); T2WI high signal and ADC values were factors influencing Ki-67 positivity,T2WI signal was positively correlated with Ki-67 positively and ADC values were negatively correlated with them (r=0.274,r=-0.476,P=0.003,P<0.001). Conclusion: In this paper,we leave aside the commonly used ultrasound and mammography examinations for breast cancer and use MRI as the main breakthrough point to investigate the relationship between T2WI signals,ADC values and body biologic factors.Most studies have focused on the ADC values and the results of MRI examinations,ignoring the role of T2WI signals in assessing the relationship between breast cancer and body biologic factors.In this paper,the combination of ADC values,T2WI signals and biologic factors is used to support the search for new targets for breast cancer treatment.The T2WI signal and ADC value are associated with the expression of cerbB-2 and Ki-67,which can be used as a reference for subsequent breast cancer treatment.

Key words： Breast cancer Magnetic resonance CerbB-2 Ki-67

基金资助:山东省妇幼保健协会科技创新项目,(编号:20210210)

引用本文:

吴丽萍, 张南, 刘文霞. 乳腺癌磁共振参数与表皮生长因子受体2 增殖细胞核抗原相关性[J]. 河北医学, 2022, 28(10): 1684-1688.
WU Liping, ZHANG Nan, LIU Wenxia. Correlation of MRI Parameters with Epidermal Growth Factor Receptor 2 and Proliferating Cell Nuclear Antigen in Breast Cancer. HeBei Med, 2022, 28(10): 1684-1688.

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http://www.hbyxzzs.cn/CN/10.3969/j.issn.1006-6233.2022.10.020 或 http://www.hbyxzzs.cn/CN/Y2022/V28/I10/1684

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