Abstract：Objective: To analyze the diagnostic value of serum amyloid protein A (SAA), retinol binding protein (RBP) and urine beta 2 microglobulin (β2-MG) in early renal injury during pregnancy hypertension disease (HDP). Methods: 120 HDP patients with gestational age of 20~40 weeks in our hospital from March 2019 to March 2021 were selected and divided into mild group (32 cases), moderate group (53 cases) and severe group (35 cases) according to the severity of the disease. In addition, 50 normal pregnant women hospitalized in the same period were selected as the control group. 3 ml of fasting elbow venous blood and 5 ml of midstream urine were collected in the morning. 24 h urine was collected after bladder emptying. The levels of SAA, RBP and urine were compared among the four groups. Receiver operating characteristic curve (ROC) was used to analyze the diagnostic value of each index for early renal injury of HDP. Results: Serum SAA, RBP and urine β2-MG averages increased gradually in the control group, mild group, moderate group, and severe group, and the differences between any two groups were statistically significant (P<0.05). There was a positive correlation between serum SAA, RBP, or urine β2-MG and 24h urinary protein level (r=0.751、0.878、0.668,P<0.05). The combined detection of serum SAA, RBP and urine β2-MG had an ROC curve area (AUC) of 0.918, a sensitivity of 0.895 and a specificity of 0.933 to predict HDP. Conclusion: Serum SAA, RBP and urine β2-MG levels can reflect the degree of kidney damage in HDP patients to a certain extent. Joint testing can improve the sensitivity and specificity of early kidney damage diagnosis in HDP patients, and it has great value for the diagnosis and assessment of the early kidney damage in HDP patients.
舒银珍, 全晖, 曾志荣, 黄琦, 蔡明燕. 血清淀粉样蛋白A 视黄醇结合蛋白和尿β2微球蛋白在妊娠期高血压疾病早期肾损伤中的诊断价值[J]. 河北医学, 2022, 28(1): 66-70.
SHU Yinzhen, QUAN Hui, ZENG Zhirong, et al. The Diagnostic Value of Serum Amyloid A, Retinol Binding Protein and Urine β2 Microglobulin in Early Renal Injury During Pregnancy Hypertension. HeBei Med, 2022, 28(1): 66-70.
[1] 彭博,段超超,王春芳.妊娠期高血压疾病视网膜病变的研究现状[J].中西医结合心脑血管病杂志,2021,19(10):1659~1661. [2] Liu CC,Hsieh TJ,Wu CF,et al.Urinary melamine excretion and increased markers of renal tubular injury in patients with calcium urolithiasis:a cross-sectional study [J].Environ Poll,2018,231(2):1284~1290. [3] 黄幸红,林裕锋,许秋桂,等.血栓弹力图和血清淀粉样蛋白A检测在妊娠子痫前期中的应用价值[J].中国当代医药,2021,28(2):155~157. [4] 中华医学会妇产科学分会.妊娠期高血压疾病学组.妊娠期高血压疾病诊治指南(2020)[J].中华妇产科杂志,2020,55(4):227~238. [5] 赵玉杰,吕艳关.纤维蛋白原与血清淀粉样蛋白A检测在子痫前期诊断中的价值[J].检验医学,2020,35(1):79~80. [6] Jalansooriya A,Jennings P,Haddad F,et al.Urinary enzyme measurements as early indicators of renal insult in type 2 diabetes[J].Brit Bio Sci,2018,64(4):153~156. [7] 何丽姣,徐静茹,王晓卫,等.血清视黄醇结合蛋白、胱抑素C水平对新生儿ABO溶血症肾功能损伤的诊断效能[J].山东医药,2019,25(27):236~238. [8] 石丹,冯文,张毅,等.血清FGF23、Apelin及尿β2-MG与妊娠期高血压疾病的相关性[J].西部医学,2021,33(5):709~713.
2022, Vol. 28 
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