Abstract：Objective: To explore the changes of serum C-peptide (CP), C-reactive protein (CRP) and Cystatin C (Cys-C) levels in patients with type 2 diabetes (T2DM) and their predictive value for macrovascular disease. Methods: A total of 85 patients with T2DM complicated with macrovascular disease in our hospital from April 2018 to March 2020 were selected as the study group, and 85 patients with pure T2DM were selected as the control group. The clinical data, serum CP, CRP, and Cys-C levels were compared between the two groups. Logistic regression was used to analyze the influencing factors of T2DM macrovascular disease. Pearson correlation analysis was used to explore the relationship between serum CP, CRP, and Cys-C levels and carotid intima-media thickness (IMT). The receiver operating characteristic (ROC) curve analysis was used to predict value of serum CP, CRP, and Cys-C levels for T2DM with macrovascular disease. Statistics of the incidence of major adverse cardiac events (MACE) in the two groups was recorded in the six-month follow-up. Results: In the study group, age ≥60 years, the proportion of diabetes ≥10 years, TG, LDL-C, carotid IMT serum CRP and Cys-C had higher levels than those of the control group, and the CP level was lower than that of the control group (P<0.05). Logistic regression model showed, age correction ≥60 years, diabetes course ≥10 years, serum TG, LDL-C levels, carotid IMT, serum CP, CRP, Cys-C levels were still related to T2DM complicated by macrovascular disease (P<0.05). Serum CP levels in patients with T2DM complicated with macrovascular disease are negatively correlated with carotid IMT, and serum CRP and Cys-C levels are positively correlated with carotid IMT (P<0.05). The maximum AUC of serum CP, CRP, and Cys-C in predicting T2DM with macrovascular disease is 0.948, the corresponding sensitivity is 90.59%, and the specificity is 96.47%. The incidence of MACE in the study group 21.18% was higher than that in the control group (9.41%) (P<0.05). Conclusion: Serum CP, CRP, and Cys-C are abnormally expressed in patients with T2DM, and each index is an influencing factor in the pathogenesis of macrovascular disease. Combined detection can provide an important reference for clinical prediction of macrovascular disease.
邢宇, 宋晓彬, 施克新, 杨梅, 冯畅, 鄢一. 2型糖尿病患者血清CP CRP Cys-C水平变化及对大血管病变的预测价值[J]. 河北医学, 2022, 28(1): 37-42.
XING Yu, SONG Xiaobin, SHI Kexin, et al. Changes of Serum CP CRP and Cys-C Levels in Patients with Type 2 Diabetes and the Predictive Value for Macrovascular Disease. HeBei Med, 2022, 28(1): 37-42.
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2022, Vol. 28 
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