Comparative Study of Dental Pulp Stem Cells Intravenous Injection and Combined Core Decompression in the Treatment of Early Steroid-Associated Femoral Head Necrosis in Rabbits
LU Yang, LIU Fei, WANG Xinmin, et al
The First Hospital of Qinhuangdao, Hebei Qinhuangdao 066000, China
Abstract：Objective: To study the therapeutic effect of intravenous application of dental pulp stem cells on early steroid-associated femoral head necrosis in rabbits, and to provide experimental data support for clinical application. Methods: Forty seven healthy adult Japanese white rabbits were randomly divided into 4 groups. There were 5 rats in group A (normal control group), 14 rats in group B (model group), 14 rats in group C (intravenous administration group) and 14 rats in group D (stem cell transplantation group). Models of femoral head necrosis were built among group A, B, and C before relative treatment was conducted to every of the three groups. After 12 weeks of modeling, the X-ray, micro CT, tissue sections and immunohistochemical indexes were collected and statistically analyzed. Results: There were significant differences between group C and group D in bone volume fraction (BV/TV), trabecular thickness (Tb.Th), trabecular number (TB.N), structural model index (SMI), bone mineral density (BMD), void lacuna rate, trabecular area ratio and VEGF (P<0.05). The indicators of stem cell transplantation group(group D) were better than those of intravenous administration group(group C). Conclusion: Both intravenous injection of dental pulp stem cells and intratunnel injection of dental pulp stem cells after core decompression are effective in the treatment of steroid induced femoral head necrosis in rabbits, and the effect of stem cell transplantation is better than that of intravenous injection.
鲁洋, 刘飞, 王新民, 许杰, 白玉玺, 吕剑. 牙髓干细胞静脉注射与联合髓芯减压治疗兔早期激素型股骨头坏死的对比研究[J]. 河北医学, 2022, 28(1): 131-136.
LU Yang, LIU Fei, WANG Xinmin, et al. Comparative Study of Dental Pulp Stem Cells Intravenous Injection and Combined Core Decompression in the Treatment of Early Steroid-Associated Femoral Head Necrosis in Rabbits. HeBei Med, 2022, 28(1): 131-136.
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2022, Vol. 28 
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