Abstract：Objective: To explore the relationship between childhood obesity and adult hypertension(HP) and left ventricular hypertrophy(LVH). Methods: A total of 450 hypertensive adults and 350 non-hypertensive adults who were examined in the second Affiliated Hospital of Shenyang Medical College from 2018 to 2019 were selected as research subjects. Patients' age range between 19 and 48, whose general data, laboratory examination index and Doppler echocardiography were completed. Retrospective survey was conducted toward selected subjects with at least 6 physical examination reports of them from childhood (6-18 years old) to adulthood. BMIs of childhood age brackets and adulthood were recorded and the trajectory curve equation of childhood BMI was constructed with the mixed effect model. The area under the curve (AUC) was recorded as AUCBMI, which represents the average level of BMI for individuals throughout childhood. Results: Spearman correlation analysis showed that childhood obesity was significantly correlated with HP and LVH in adults(r=0.545,r=0.478). Non-conditional logistic analysis showed excluding age, gender and other possible confounding factors, childhood obesity could increase the risk of HP and LVH in adults (P<0.05).The risk of adult HP and LVH was the highest when childhood obesity was extended to adult obesity (P<0.05).Conclusion: Childhood obesity is significantly related to HP and LVH in adults, so the window of opportunity for prevention and treatment of cardiovascular chronic diseases related to obesity should be moved from adulthood to childhood. It is advocated to identify high-risk children with obesity early, control risk factors from childhood, achieve prevention and treatment window "move down" , in order to reduce the risk of cardiovascular disease in adults. The quantification of the regulatory effect of childhood obesity on adult blood pressure and left ventricular remodeling will promote the development of new prevention and intervention strategies.
吴桂平, 刘兆奕, 林瑶瑶. 儿童期肥胖与其成人高血压和左心室肥厚的相关性研究[J]. 河北医学, 2022, 28(1): 127-130.
WU Guiping, LIU Zhaoyi, et al. Study on the Relationship Between Childhood Obesity and Adult Hypertension and Left Ventricular Hypertrophy. HeBei Med, 2022, 28(1): 127-130.
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2022, Vol. 28 
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