Correlation Analysis between Levels of Homocysteine Apolipoprotein A/Apolipoprotein B and Coagulation Indexes in Patients with Chronic Obstructive Pulmonary Disease
ZHAO Xuefeng, HAN Jingxu, YUE Hongyun, et al
Shijiazhuang People's Hospital, Hebei Shijiazhuang 050000, China
Abstract：Objective: To analyze the correlation between level of serum homocysteine (Hcy), apolipoprotein A1 (Apo A1)/apolipoprotein B100 (Apo B100) and blood coagulation indexes in patients with chronic obstructive pulmonary disease (COPD). Methods: The 188 COPD patients admitted to our hospital from Jan 2017 to Dec 2019 were divided into venous thromboembolism (VTE) group (n=92) and non-VTE group (n=96), and the general information of the two groups were compared. Other items of the two groups were compared too, including serum Hcy, Apo A1, Apo B100, Apo A1/Apo B100 levels and coagulation indexes such as activated partial thromboplastin time (APTT), fibrinogen (FIB), prothrombin time (PT), plasma viscosity (PV), D-dimer (DD) and antithrombin III (AT-III) activity. Then correlation analysis between serum Hcy, Apo A1, Apo B100, Apo A1/Apo B100 levels and coagulation indexes of COPD patients were performed. Results: The serum levels of Hcy, Apo B100, FIB, PV and DD in the VTE group were significantly higher than those in the non-VTE group (P<0.05 or P<0.01). The serum levels of Apo A1, Apo A1/Apo B100 and AT-III in the VTE group was significantly lower than those in the non-VTE group (P<0.05 or P<0.01). The levels of Hcy and Apo B100 in the serum of patients with COPD are significantly positively correlated with FIB, PV, and DD and other coagulation indicators (P<0.001), and significantly negatively correlated with AT-III (P<0.001); while Apo A1 and Apo A1/Apo B100 level is significantly negatively correlated with FIB, PV, DD and other coagulation indicators (P<0.001), and there is a significant positive correlation with AT-III (P<0.001). Conclusion: Serum Hcy, Apo A1, Apo B100, Apo A1/Apo B100 levels in COPD patients are correlated with the occurrence of VTE. Clinical monitoring of serum Hcy, Apo A1 and Apo B100 levels is of great value in evaluating the occurrence of VTE in COPD patients.
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2021, Vol. 27 
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