妊娠期糖尿病对新生儿脑损伤影响的meta分析

doi:10.3969/j.issn.1006-6233.2021.09.015

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摘要 目的: 通过运用meta分析,探讨妊娠期糖尿病与新生儿脑损伤之间关联性。方法: 检索的数据库包括:中国知网(CNKI)、中国生物医学文献数据库(CBM)、万方数据库、维普系列数据库(VIP)、Cochrane Library、PubMed、web of Ssience、EMBASE以及其他途径手工检索。内容是有关妊娠期糖尿病对新生儿脑损伤影响。文献检索日期截至为2021年3月12日。采用固定(随机)效应模型对各个文献报告的研究结果进行合并,并计算比值比(OR值)及相应95%可信区间(CI)。查找异质性原因及分析潜在的发表偏倚。结果: 共检索到相关文献421篇,最终纳入的文献数量为13篇(2077例患儿),其中实验组881例,对照组1196例。纳入文献均为病例对照研究,NOS量表评分结果示均为高质量文献。Meta分析结果示,不同研究间存在异质性(I²=73%>50%,P<0.0001),经随机效应模型计算得出妊娠期糖尿病对新生儿脑损伤影响OR值为21.91,(95%CI:8.98~53.50)。Begg检验和Egger's检验显示,纳入文献不存在发表偏倚(P>0.05)。结论: 妊娠期糖尿病会增加新生儿脑损伤的患病风险。

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关键词 ：妊娠期糖尿病, 新生儿, 脑损伤, Meta分析

Abstract：Objective: To analyze the relationship between gestational diabetes mellitus and neonatal brain injury by meta analysis. Methods: The databases included CNKI, CBM, Wanfang, VIP, Cochrane Library, PubMed, web of science, EMBASE and other manual searches. The content is about the effect of gestational diabetes mellitus on neonatal brain injury. The date of literature search is March 12, 2021. The fixed (random) effect model was used to merge the results of the studies reported in the literature, and the odds ratio (or) and the corresponding 95% confidence interval (CI) were calculated. The causes of heterogeneity and analyze potential publication bias were explored. Results: A total of 421 articles were searched, and 13 articles were finally included in this analysis (2077 children), including 881 cases in the experimental group and 1196 cases in the control group. The included literatures are all case-control studies, and the NOS scale score results show that they are all high-quality literature. The Meta analysis showed heterogeneity across all studies (I²= 73%>50%,P<0.0001). The random effects model showed that the OR of influence of gestational diabetes mellitus on neonatal brain injury with an OR of 21.91(95%CI:8.98-53.50). The Begg test and Egger's test showed that there was no publication bias in the included literature (P>0.05) .Conclusion: Gestational diabetes mellitus increases the risk of brain ingury in newborns.

Key words： Gestational diabetes mellitus Infants newborn Brain injuries Meta-analysis

基金资助:河北省重点研发计划项目民生科技专项,(编号:20377746D)

通讯作者: 任常军

引用本文:

王杰, 郝玲, 李贺嘉, 苗佳丽, 赵倩, 任常军. 妊娠期糖尿病对新生儿脑损伤影响的meta分析[J]. 河北医学, 2021, 27(9): 1472-1476.
WANG Jie, HAO Ling, LI Hejia, et al. Meta Analysis of the Effect of Gestational Diabetes Mellitus on Neonatal Brain Injury. HeBei Med, 2021, 27(9): 1472-1476.

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http://www.hbyxzzs.cn/CN/10.3969/j.issn.1006-6233.2021.09.015 或 http://www.hbyxzzs.cn/CN/Y2021/V27/I9/1472

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