Abstract：Objective: To investigate the diagnostic values of serum amyloid A (SAA) in peritoneal dialysis (PD) related peritonitis, providing a theoretical basis for clinical diagnosis and treatment. Methods: In this study, 68 patients with PD related peritonitis were included. And 30 patients with maintenance PD without PD related peritonitis were selected as the control group. Serum was collected before and after diagnosis and treatment, respectively. Meanwhile, the curative effect was evaluated after treatment. The serum levels of SAA were measured by ELISA. Receiver operating characteristic curve (ROC) was used to evaluate diagnostic value of SAA for PD related infection. Results: There was no significant difference in clinical data between the two groups (all P>0.05). Compared with patients without PD related peritonitis, the serum SAA level in patients with PD related peritonitis was significantly increased (P<0.01). The sensitivity and specificity of SAA in the diagnosis of PD related peritonitis were 89.32% and 78.89%, respectively. For PD related peritonitis patients with atypical clinical symptoms, the serum SAA level was also significantly increased (P<0.01). Among 68 peritonitis patients included in this study, 54 cases were cured, 8 cases were persistent infection and 6 cases were failed. The serum SAA level in the cured group was significantly lower than that in the persistent infection group, but was higher than the normal level, while the SAA level in the failure group continued to be high. The difference was statistically significant (all P<0.05). Conclusion: Serum SAA level has very important value in the diagnosis and curative effect evaluation of PD related peritonitis.
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2021, Vol. 27 
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