Abstract：Objective: To analyze the value of urinary retinol binding protein (RBP), urinary liver-type fatty acid binding protein (L-FABP), blood fibroblast growth factor-21 (FGF-21) and transforming growth factor-β (TGF-β) in the diagnosis of early diabetic nephropathy (DN). Methods: The clinical data of 124 patients with type 2 diabetes mellitus treated in the hospital from January 2018 to January 2020 were retrospectively analyzed. The occurrence of DN in all patients was counted and divided into groups. Referred to the guidelines, the patients with DN were divided into different stages. Enzyme linked immunosorbent assay was used to analyze the levels of urinary RBP, urinary L-FABP, serum FGF-21 and TGF-β of patients. The levels of urinary RBP, urinary L-FABP, serum FGF-21 and TGF-β in the DN group and the non DN group were compared. The levels of urinary RBP, urinary L-FABP, serum FGF-21 and TGF-β of DN with different stages, the diagnostic efficacy of urinary RBP, urinary L-FABP, serum FGF-21 and TGF-β levels in patients with diabetes mellitus were analyzed. Results: Among 124 patients with type 2 diabetes mellitus, there were 35 patients with DN and 89 patients without DN; the levels of urinary RBP, urinary L-FABP, serum FGF-21 and TGF-β in DN group were all higher than those in non DN group, with a statistical significant difference (P<0.05); among the 35 cases of patients with DN, 12 cases were DN stage 1, 13 cases were DN stage 2 and 10 cases were DN stage 3; the levels of urinary RBP, urinary L-FABP, serum FGF-21 and TGF-β in DN stage 3 group respectively higher than those in DN stage 1 group and DN stage 2 group, with a statistical significant difference (P<0.05); comparing the levels of urinary RBP, urinary L-FABP, serum FGF-21 and TGF-β in DN stage 1 and 2 groups, there was no statistical significant difference (P>0.05); the area under the curve (AUC) of urinary RBP, urinary L-FABP, serum FGF-21, TGF-β alone and in combination of detection for the diagnosis of DN in patients with diabetes mellitus and the differentiation of DN stages were all >0.80, all with certain diagnostic and differential value. Conclusion: The combination of urinary RBP, urinary L-FABP, serum FGF-21 and TGF-β has high application value in the diagnosis of early DN, and can be used to differentiate the stages of DN.
梅笑雪, 马毓敏, 赵郁松. 尿RBP 尿L-FABP 血FGF-21 TGF-β联合诊断早期糖尿病肾病的价值[J]. 河北医学, 2021, 27(8): 1358-1363.
MEI Xiaoxue, MA Yumin, ZHAO Yusong. The Diagnosis Value of Urinary RBP Urinary L-FABP Serum FGF-21 and TGF-β in Combination for Early Diabetic Nephropathy. HeBei Med, 2021, 27(8): 1358-1363.
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2021, Vol. 27 
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