Abstract：Objective: To observe the effect of continuous blood purification and ordinary hemodialysis on patients with uremia, and to conduct a comparative study. Methods: 180 cases of uremia patients treated in our hospital were selected and randomly divided into control group and observation group, 90 cases in each group. The control group underwent conventional dialysis treatment, with each dialysis of 4 hours, 3 times a week, and the intervention lasted 3 months. The observation group underwent a continuous blood purification dialysis treatment, 3 times during the day and 1 time at night in a day, and the intervention lasted 3 months. The clinical efficacy and serum HMG-1 and TNF-α levels in the two groups were observed. Results: The observation group had 85 effective cases, accounting for 94.4%; the control group had an effective rate of 76.6% (P<0.05). After treatment, the renal function indexes of the two groups decreased; difference before and after treatment in the observation group was greater than that in the control group (P<0.05). After treatment, difference before and after treatment of HMG-1 and TNF-α in the observation group was significantly greater than that in the control group (P<0.05). After treatment, the levels of LA, CRP, and PCT in the two groups decreased compared with those before treatment. After treatment, difference before and after treatment of LA, CRP, and PCT in the treatment group was greater than that in the control group (P<0.05). The outcome of the patients was followed up for 28 days. As a result, there were 10 deaths in the control group, with a case fatality rate of 11.1%; 2 cases in the treatment group died, with a case fatality rate of 2.22% (P<0.05). Conclusion: Continuous blood purification is effective in treating uremia and can effectively reduce the levels of HMG-1 and TNF-α in serum, at the same time improve the survival rate of patients.
李刚, 郭豪. 连续性血液净化与普通血液透析对尿毒症患者的疗效对比研究[J]. 河北医学, 2021, 27(8): 1344-1347.
LI Gang, GUO Hao. Comparison of Efficacy of Continuous Blood Purification and Ordinary Hemodialysis on Patients with Uremia. HeBei Med, 2021, 27(8): 1344-1347.
2021, Vol. 27 
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