Abstract：Objective: To clarify the correlation between ATP binding cassette transporter G2 (ABCG2) rs3114018 and primary gout and provide genetic markers for the early diagnosis of primary gout in Haikou. Methods: A total of 177 patients with gout admitted to our hospital from January 2019 to June 2020 were selected as the experimental group, and 191 healthy controls as the healthy group. Peripheral blood was extracted for detection. High throughput sequencing was used to genotype the rs3114018 locus of ABCG2.The correlation between the genotypes of rs3114018 and the occurrence of primary gout in Haikou was analyzed by statistical method. Results: The frequency of AC type was 35.02% in gout patients and 10.99% in normal population. The frequency of CC type was 35.59% in gout patients and 21.98% in the normal population. The frequency of each genotype in the gout group was statistically different from that in the normal group (P<0.001). The polymorphism of ABCG2 gene rs3114018 was significantly correlated with serum uric acid, blood glucose, creatinine, alanine aminotransferase and glutamate aminotransferase. Compared with AA genotype, the incidence risk of AC carriers increased by 3.273 times, which was 2.642 times after correction, and the incidence risk of CC carriers increased by 3.825 times, which was 3.281 times after correction. Conclusion: The polymorphism of ABCG2 gene rs3114018 is associated with the incidence of primary gout in Haikou, which is a risk factor for the incidence of gout, and is expected to provide a new genetic diagnostic marker for primary gout in Haikou.
周胃雯, 王雪娇, 唐小波, 孙少清, 符丽娜, 林先珍. 海口市原发性痛风患者ABCG2基因rs3114018位点单核苷酸多态性分析[J]. 河北医学, 2021, 27(8): 1317-1321.
ZHOU Weiwen, TANG Xiaobo, SUN Shaoqing, et al. An Analysis of Single Nucleotide Polymorphism at Rs3114018 of ABCG2 Gene in Patients with Primary Gout in Haikou City. HeBei Med, 2021, 27(8): 1317-1321.
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2021, Vol. 27 
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