Abstract：Objective: To explore the predictive value of serum levels of HMGB1, miR-200-c-3p and cTn Ⅰ level on the prognosis of neonatal respiratory distress syndrome. Methods: 120 children with NRDS treated between January 2016 and December 2019 in our hospital were chosen and divided into mild group (n=72, level I and II by X-ray results), severe group (n=48, level III and IV by X-ray results).In addition, 40 normal newborns in our hospital during the same period were selected as the control group. Serum HMGB1, miR-200-c-3p and cTn I level differences were compared between three groups and prognosis was predicted. Results: Serum HMGB1, miR-200c-3p and cTn I levels in the three groups were: severe grouP>mild group>control group (P<0.05).During hospitalization, 34 (28.33%) of 120 patients with NRDS died and 86 (71.67%) survived. There were no significant differences in age, sex, birth weight, maternal age, cesarean section, time of dyspnea, maternal diabetes, maternal hypertension, meconium inhalation, intrauterine distress, neonatal asphyxia, etc. between the two groups (P>0.05), but the differences in disease, HMGB1, miR-200c-3p and cTn I between the two groups were statistically significant (P<0.05). ROC curve analysis showed that the AUC of HMGB1, miR-200c-3p and CTN I in NRDS patients were 0.933, 0.892 and 0.766, with high accuracy. Taking the maximum tangent point of Youden index at the upper left of ROC curve as the optimal critical value, the sensitivity and specificity of HMGB1, miR-200c-3p and CTN I were 91.2%, 82.4%, 50.0% and 91.9%, 100.0% , 100.0% at this point, indicating a high predictive value. The AUC of the three combined predictions was 0.925, and the sensitivity and specificity were 85.3% and 98.8%, indicating high predictive value. Conclusion: Serum HMGB1, miR-200-c-3p and cTn I levels in children with NRDS has high expression, and is closely related to the degree of disease with high value of prognostic assessment.
霍惠仪, 卢泳雪. 血清HMGB1 miR-200c-3p及cTnⅠ水平对新生儿呼吸窘迫综合征预后的预测价值[J]. 河北医学, 2021, 27(7): 1210-1214.
HUO Huiyi, LU Yongxue. Predictive Value of Serum Levels of HMGB1, MiR-00-C-3p and CTn Ⅰ on the Prognosis of Neonatal Respiratory Distress Syndrome. HeBei Med, 2021, 27(7): 1210-1214.
2021, Vol. 27 
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