Clinical Efficacy and Mechanism of Hulisan Capsule combined Nail Internal Fixation on Garden Type Ⅲ and Ⅳ Femoral Neck Fractures in Young and Middle-aged Patients
WANG Rongsheng, HAN Xue, WANG Jing, et al
The Central Hospital of Chengde, Hebei Chengde 067000, China
Abstract：Objective: To investigate the clinical curative effect and the mechanism of Hulisan capsule combined nail internal fixation on GardenⅢ, Ⅳyoung and middle-aged femoral neck fracture.Methods: 130 patients with femoral neck fractures were divided into control group and combined treatment group. Patients in the control group were treated with nail internal fixation, and patients in the combined treatment group were treated with Hulisan capsule after nail internal fixation. Fracture healing, femoral head necrosis rate, incidence of femoral neck shortening, serum oxidative stress and inflammatory factors concentration and hip joint function of patients in the two groups were observed. Results: After surgery, the patients received Hulisan capsule combined nail internal fixation showed the fracture healing time was significantly shorter (P<0.01) and fracture healing rate increased significantly (P<0.05), and 6 months after operation, femoral head necrosis rate and incidence of femoral neck shortening significantly decreased (P<0.05), serum oxidative stress indicators increased significantly(P<0.01), serum inflammatory factors indicators decreased significantly(P<0.01),Harris hip score increased significantly (P<0.01), and Harris hip function evaluation effect of excellent and good rate increased significantly (P<0.05).Conclusion: Hulisan capsule combined nail internal fixation treatment significantly improved fracture healing and femoral head necrosis rate, improve the patient's hip joint function of GardenⅢ, Ⅳ young and middle-aged femoral neck fracture. Its mechanism of action may be achieved through anti-oxidative stress and anti-inflammation.
王荣升, 韩雪, 王静, 徐文硕, 陈香云, 段惠潇, 金宝城. 虎力散胶囊联合空心钉内固定治疗Garden Ⅲ Ⅳ型中青年股骨颈骨折的临床疗效及其机制分析[J]. 河北医学, 2021, 27(7): 1104-1107.
WANG Rongsheng, HAN Xue, WANG Jing, et al. Clinical Efficacy and Mechanism of Hulisan Capsule combined Nail Internal Fixation on Garden Type Ⅲ and Ⅳ Femoral Neck Fractures in Young and Middle-aged Patients. HeBei Med, 2021, 27(7): 1104-1107.
[1] Florschutz AV, Langford JR, Haidukewych GJ, et al. Femoral neck fractures: current management [J].Orthop Trauma,2015, 29(3):121~129. [2] Sprague S, Slobogean GP, Scott T, et al. Young femoral neck fractures: are we measuring outcomes that matter[J]. Injury,2015, 46(3):507~514. [3] Kazley JM, Banerjee S, Abousayed MM, et al. Classifications in brief: garden classification of femoral neck fractures [J].Clin Orthop Relat Res, 2018, 476(2):441~445. [4] Slobogean GP, Sprague SA, Scott T, et al. Complications following young femoral neck fractures [J]. Injury,2015, 46(3):484~491. [5] Zhang K, Niu LC, Yuan FJ, et al. Research on promotory effect of traditional Chinese medicine on fracture healing in cell and molecular level [J]. Zhongguo Gu Shang,2017, 30(8):777~782. [6] Li R, Fan L, Ma F, et al. Effect of etomidate on the oxidative stress response and levels of inflammatory factors from ischemia-reperfusion injury after tibial fracture surgery [J]. Exp Ther Med,2017, 13(3):971~975. [7] Kostenuik P, Mirza FM. Fracture healing physiology and the quest for therapies for delayed healing and nonunion [J].Orthop Res,2017, 35(2):213~223. [8] Einhorn TA, Gerstenfeld LC. Fracture healing: mechanisms and interventions [J].Nat Rev Rheumatol,2015, 11(1):45~54. [9] 周建华.虎力散胶囊治疗膝关节骨性关节炎疗效研究[J].新中医, 2017, 49(4): 50~52. [10] 王丰.虎力散外用治疗股骨粗隆间骨折术后手术切口肿胀疗效观察[J].中国中医急症, 2012, 21(11): 1849~1850. [11] Wang Y, Huang X, Tang Y, et al.Effects of panax notoginseng saponins on the osteogenic differentiation of rabbit bone mesenchymal stem cells through TGF-β1 signaling pathway [J]. BMC Complement Altern Med,2016, 16(1):319.
2021, Vol. 27 
冀公网安备13080202000677号