Abstract：Objective: To analyze the correlation between polymorphism of type I myosin (myosin1H) gene and the susceptibility of skeletal mandibular retrusion (MR) in Mongolian. Methods: A total of 61 patients with skeletal type II malocclusion (mainly on MR) who were treated in stomatology department of the hospital were made the observation group, while another 61 patients with skeletal type I malocclusion were made the control group. All were Mongolian cases in Inner Mongolia. The distribution of Myosin1H gene polymorphisms at rs11611277 and rs3825393 loci was detected by polymerase chain reaction-restriction fragments length polymorphism (PCR-RELP). The correlation between Myosin1H gene polymorphism and the susceptibility of skeletal MR was analyzed. Results: The genotype carrying AG and frequency of A allele in observation group were 60.66% and 38.52%, higher than those in control group (24.59%, 23.77%) (P<0.05). In observation group, SNB angle and Z angle in patients carrying AG genotype at rs3825393 locus wee (81.49±1.73)° and (62.25±4.75)°, lower than those carrying GG genotype [(82.18±1.57)°, (82.16±1.95)°] and AA genotype [(72.14±5.11)° , (73.52±6.34)°] (P<0.05), while ANB angle [(5.91±0.75)°] was higher than those carrying GG genotype [(4.21±1.45)°] and AA genotype [(4.19±0.65)°] (P<0.05). Taking GG genotype as control group, carrying AG genotype of Myosin1H gene at rs3825393 could increase the susceptibility to MR by 2.571 times (P<0.05). Conclusion: G→A mutation of Myosin1H gene at rs3825393 locus is related to the susceptibility of MR in Mongolian. The risk of susceptibility to MR is higher in patients with AG genotype at the locus.
李晓晖, 程书玉, 巴格那, 陈玉友. Myosin1H基因多态性与蒙古族骨性下颌后缩易感性的关系[J]. 河北医学, 2021, 27(6): 901-905.
LI Xiaohui, CHENG Shuyu, BA Gena, et al. The Correlation Between Myosin1H Gene Polymorphism and the Susceptibility of Skeletal Mandibular Retrusion in Mongolian. HeBei Med, 2021, 27(6): 901-905.
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2021, Vol. 27 
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