Abstract：Objective: To analyze the clinical value of serum high mobility group protein-1 (HMGB-1), macrophage migration inhibitory factor (MIF) and platelet-derived growth factor (PDGF) in predicting short-term prognosis of acute cerebral hemorrhage. Methods: Clinical data of 106 patients with acute cerebral hemorrhage who were treated in the hospital between May 2016 and May 2020 were retrospectively analyzed. According to the severity of nervous system damage, the patients were divided into mild group (NIHSS 1 ~ 4 points, n=23), moderate group (NIHSS 5 ~ 20 points, n=53) and severe group (NIHSS > 20 points, n=30). Meanwhile, 40 healthy controls were made the control group. Three months later, according to the Glasgow Outcome Score (GOS), the patients were divided into favorable prognosis group (GOS 4～5 points, n=60) and bleak prognosis group (GOS ≤ 3 points, n=46). Serum HMGB-1, MIF and PDGF levels were detected, and their clinical value in predicting short-term prognosis of acute cerebral hemorrhage was analyzed with the area under the ROC curve (AUC). Results: Serum HMGB-1, MIF and PDGF levels were higher in patients with cerebral hemorrhage than the control group (P<0.05), higher in the severe group than the mild and moderate groups, higher in the moderate group than the mild group (P<0.05), and higher in the favorable prognosis group than the bleak prognosis group (P<0.05). The sensitivity and AUC area of serum HMGB-1, MIF and PDGF were higher than those of single detection (P<0.05). Conclusion: Serum HMGB-1, MIF and PDGF have high value in predicting short-term prognosis of acute cerebral hemorrhage, which can be used for treatment guidance.
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2021, Vol. 27 
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