Effects of Modified Liuwei Dihuang Decoction Combined with Cardiopulmonary Rehabilitation Training on Exercise Tolerance, Serum IL-6 IL-8 and Cys-C Levels in Patients with Stable COPD
ZHENG Jun, HUANG Pei, WU Caihua
Wuhan Hospital of Integrated Traditional Chinese and Western Medicine, Hubei Wuhan 430022, China
Abstract：Objective: To explore the effects of modified Liuwei Dihuang Decoction combined with cardiopulmonary rehabilitation training on exercise tolerance, serum interleukin-6 (IL-6), interleukin-8 (IL-8) and cystatin-C (Cys-C) levels in patients with stable chronic obstructive pulmonary disease (COPD). Methods: 192 patients with stable COPD admitted to the hospital from May 2019 to May 2020 were enrolled and divided into observation group and control group by random number table method, 96 cases in each group. The control group was treated with routine western medicine, while observation group was given modified Liuwei Dihuang Decoction combined with cardiopulmonary rehabilitation training. The clinical curative effect, scores of TCM symptoms, exercise tolerance, pulmonary function, serum IL-6, IL-8 and Cys-C levels before and after treatment were compared between the two groups. Results: The total response rate of clinical treatment in observation group was higher than that in control group (94.79% vs 86.46%) (P<0.05). After treatment, scores of TCM symptoms were significantly decreased, while 6-min walk test (6MWT) was significantly increased in both groups (P<0.05). The difference values of the above two indexes before and after treatment in observation group were higher than those in control group (P<0.05). After treatment, forced vital capacity (FVC), forced expiratory volume in 1 second (FEV1), maximum ventilation per minute (MVV) and FEV1/FVC were significantly increased in both groups (P<0.05). The difference values of the above four indexes before and after treatment in observation group were higher than those in control group (P<0.05). After treatment, levels of IL-6, IL-8 and Cys-C were significantly decreased in both groups (P<0.05). The difference values of the above three indexes before and after treatment in observation group were higher than those in control group (P<0.05). Conclusion: The modified Liuwei Dihuang Decoction combined with cardiopulmonary rehabilitation training can improve the clinical curative effect on patients with stable COPD, improve exercise tolerance, relieve clinical symptoms, promote recovery of pulmonary function, and reduce levels of serum IL-6, IL-8 and Cys-C.
2021, Vol. 27 
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