COPD患者血清sCD40L TNF-α及MMP-9水平及意义

doi:10.3969/j.issn.1006-6233.2021.05.010

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摘要 目的: 观察慢性阻塞性肺病(chronic obstructive pulmonary disease,COPD)患者血清可溶性CD40配体(Soluble Cluster of differentiation 40 ligand,sCD40L)、肿瘤坏死因子α(tumor necrosis factor-α,TNF-α)及基质金属蛋白酶9(matrix metalloproteinase-9,MMP-9)的表达水平,并分析其检测意义。方法: 选取本院82例COPD患者,按照临床分期分为急性加重期组(n=46)与临床缓解期组(n=36),并取同期40例体检健康者为对照组,比较三组血清sCD40L、TNF-α、MMP-9表达水平与肺功能指标[1s用力呼气容积(FEV1)、用力肺活量(FVC)、FEV1/FVC、FEV1占预计值百分比(FEV1%)],并进行相关性分析。结果: 急性加重期组血清sCD40L、TNF-α、MMP-9表达水平明显高于临床缓解期组与对照组(P<0.017),且临床缓解期组显著高于对照组(P<0.017);急性加重期组FEV1、FVC、FEV1/FVC、FEV1%显著低于临床缓解期组与对照组(P<0.017),临床缓解期组明显低于对照组(P<0.017);COPD患者血清sCD40L、TNF-α、MMP-9水平与肺功能(FEV1/FVC、FEV1%)呈负相关(P<0.05)。结论: COPD患者存在血清sCD40L、TNF-α、MMP-9表达水平升高趋势,特别是急性加重期患者升高更为显著,sCD40L、TNF-α、MMP-9水平越高,患者肺功能越差,其检测可为COPD病情评估提供有效依据。

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关键词 ：慢性阻塞性肺病, 可溶性CD40配体, 肿瘤坏死因子α, 基质金属蛋白酶9

Abstract：Objective: To observe the expression levels of serum soluble CD40 ligand (sCD40L), tumor necrosis factor α (TNF-α) and matrix metalloproteinase 9 (MMP-9) in patients with chronic obstructive pulmonary disease (COPD) and analyze their significance. Methods: 82 patients with COPD were selected and divided into acute exacerbation group (n = 46) and clinical remission group (n = 36) according to the clinical staging. Meanwhile, 40 healthy people were made the control group. The expression levels of serum sCD40L, TNF-α and MMP-9 and lung function indexes [forced expiratory volume in 1s (FEV1), forced vital capacity (FVC), FEV1/FVC, the percentage of FEV1 in predicted value (FEV1%)] were compared among the 3 groups, and correlation analysis was performed. Results: The order of expression levels of serum sCD40L, TNF-α and MMP-9 in the 3 groups from high to low was as follows: the acute exacerbation group, the clinical remission group, the control group (P<0.017). The order of FEV1, FVC, FEV1/FVC and FEV1% in the 3 groups from low to high was as follows: the acute exacerbation group, the clinical remission group, the control group (P<0.017). Serum sCD40L, TNF-α and MMP-9 levels were negatively correlated with lung function (FEV1/FVC, FEV1%) in patients with COPD (P<0.05). Conclusion: The expression levels of serum sCD40L, TNF-α and MMP-9 in patients with COPD show an increasing trend, especially in patients with acute exacerbation. The higher the sCD40L, TNF-α and MMP-9 levels, the worse the lung function. The detection of the three indexes can provide an effective basis for the evaluation of COPD.

Key words： Chronic obstructive pulmonary disease Soluble CD40 ligand Tumor necrosis factor alpha Matrix metalloproteinase 9

基金资助:四川省卫生厅科研课题,(编号:120536)

通讯作者: 蔡晓玉

引用本文:

符英, 蔡晓玉, 钟巧, 魏华华, 常越. COPD患者血清sCD40L TNF-α及MMP-9水平及意义[J]. 河北医学, 2021, 27(5): 746-751.
FU Ying, CAI Xiaoyu, ZHONG Qiao, et al. Serum Levels and Significance of SCD40L TNF-α and MMP-9 in Patients with COPD. HeBei Med, 2021, 27(5): 746-751.

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http://www.hbyxzzs.cn/CN/10.3969/j.issn.1006-6233.2021.05.010 或 http://www.hbyxzzs.cn/CN/Y2021/V27/I5/746

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