Effects of Nimodipine Combined with Sodium Valproate on Hemodynamic Parameters Inflammatory Factors and Neurological Function in Patients with Acute Cerebral Hemorrhage
LIANG Shuang, TUEERHONG·Tuerxun, LIU Bo
The First Affiliated Hospital of Xinjiang Medical University, Xinjiang Urumqi 830000, China
Abstract：Objective: To observe the effects of nimodipine combined with sodium valproate on hemodynamic parameters, inflammatory factors and neurological function in patients with acute cerebral hemorrhage.Methods: 160 patients with acute cerebral hemorrhage were divided into observation group and control group according to the simple random grouping, with 80 cases in each group. The two groups were given conventional neurological treatment, and control group was given sodium valproate, and observation group was combined with nimodipine on the basis of control group. The neurological function [National Institutes of Health Stroke Scale (NIHSS), neuron-specific enolase (NSE)], hemodynamic parameters [mean flow velocity (Vm), peak systolic blood velocity (Vs), pulsatility index (PI), resistance index (RI) ], intracranial state-related indicators (intracranial pressure, intracranial hematoma volume) and levels of inflammatory factors [interleukin-6 (IL-6), tumor necrosis factor (TNF-α), high-sensitivity C-reactive protein (hs-CRP)] were compared between the two groups before treatment and after 2 weeks of treatment, and the safety of medication was evaluated through adverse reactions after treatment. Results: After 2 weeks of treatment, the NIHSS scale score, NSE, RI, intracranial pressure, intracranial hematoma volume, and levels of IL-6, TNF-α and hs-CRP in the two groups showed downward trends compared with those before treatment (all P<0.05), and the decreases were greater in observation group (P<0.05). The levels of Vm, Vs and PI showed upward trends compared with those before treatment (all P<0.05), and the increases were greater in observation group (P<0.05). There was no statistically significant differences in the total incidence rate of adverse reactions between the two groups (χ2=0.132, P=0.717). Conclusion: Nimodipine combined with sodium valproate can effectively improve cerebral blood perfusion and promote the recovery of neurological function in patients with acute cerebral hemorrhage, and can further reduce the inflammatory response and further lower intracranial pressure and intracranial hematoma volume. And it is favorable to disease outcomes.
梁爽, 吐尔洪·吐尔逊, 刘波. 尼莫地平联合丙戊酸钠治疗对急性脑出血患者血流动力学参数炎性因子及神经功能的影响[J]. 河北医学, 2021, 27(4): 673-677.
LIANG Shuang, TUEERHONG·Tuerxun, LIU Bo. Effects of Nimodipine Combined with Sodium Valproate on Hemodynamic Parameters Inflammatory Factors and Neurological Function in Patients with Acute Cerebral Hemorrhage. HeBei Med, 2021, 27(4): 673-677.
2021, Vol. 27 
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