Abstract：Objective: To observe the effect of total glucosides of paeony on inflammatory markers in patients with rheumatoid arthritis (RA). Methods: The data of patients with RA were collected from January 2018 to December 2019. A total of 120 patients were randomly divided into the observation group and the control group, with 60 cases in each group. They were treated with TGP combined with leflunomide and with leflunomide alone. Inflammatory indexes, joint function improvement and total effective rate were compared between the two groups before and after treatment. Results: The serum rheumatoid factor (RF), erythrocyte sedimentation rate (ESR), and serum C-reactive protein (CRP) indexes were all reduced after treatment, P<0.05, compared with before treatment. The inflammation indexes of the observation group were lower, compared with those of the control group. (P<0.05), statistically significant; there was no statistically significant difference in grip strength and morning stiffness time between the groups before treatment (P>0.05). After treatment, the observation group had improved grip strength and shortened morning stiffness time, which was better than the control group. The difference was statistically significant (P<0.05); the total effective rate of the observation group was significantly higher than that of the control group (93.3% vs 70.0%), and the difference was statistically significant (P<0.05). Conclusion: The total glucosides of paeony in the treatment of RA have a significant effect on the improvement of inflammatory indicators and morning stiffness symptoms in patients. It is beneficial to improve the level of grip strength and has a reliable therapeutic effect. It is worthy of clinical promotion.
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2021, Vol. 27 
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